基本信息
浏览量:65
职业迁徙
个人简介
We have an active research group focused on the function, dysfunction and restoration of the auditory system. Our goal is to understand how stimuli from the external world, such as sound, gravity and head movements are converted into electrical signals, how the information is encoded and how it is transmitted to the brain. We want to understand why genetic mutations cause hearing loss and vestibular dysfunction. We are using this information to design novel therapeutic innervations to treat deafness and balance disorders.
Recent work has focused on gene therapy approaches for restoration of function at the cellular, systems, and behavioral levels. Together with collaborators, we have also devised methods for generation of inner ear organoids from mouse and human stem cells. We plan to use the inner ear organoids as an abundant source of sensory hair cells to enable accelerated translation of novel therapeutics to the clinic.
Recent work has focused on gene therapy approaches for restoration of function at the cellular, systems, and behavioral levels. Together with collaborators, we have also devised methods for generation of inner ear organoids from mouse and human stem cells. We plan to use the inner ear organoids as an abundant source of sensory hair cells to enable accelerated translation of novel therapeutics to the clinic.
研究兴趣
论文共 126 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mary G. Chaves,Jeffrey R. Holt
引用0浏览0WOS引用
0
0
Neuronno. 20 (2023): 3195-3210.e7
Science translational medicineno. 702 (2023)
引用2浏览0WOS引用
2
0
Audiology & neuro-otologyno. 6 (2023): 1-13
Arnaud P J Giese,Wei-Hsiang Weng,Katie S Kindt,Hui Ho Vanessa Chang,Jonathan S Montgomery,Evan M Ratzan,Alisha J Beirl, Roberto Aponte Rivera,Jeffrey M Lotthammer,Sanket Walujkar, Mark P Foster,Omid A Zobeiri,
bioRxiv : the preprint server for biology (2023)
引用1浏览0WOS引用
1
0
Edward S A van Beelen,Wouter H van der Valk,Thijs O Verhagen,John C M J de Groot, Margot A Madison, Wijs Shadmanfar,Erik F Hensen,Jeroen C Jansen,Peter Paul G van Benthem,Jeffrey R Holt,Heiko Locher
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn