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Below are some of the funded projects in Dr. Keller’s laboratory which are focused on aging, oxidative stress, proteasome, and Alzheimer’s disease research. In addition to these projects, Dr. Keller is working on 2 new major research efforts. First, Dr. Keller is working on understanding the ability of a high fat diet to modulate brain function and brain pathology during aging. These efforts are a part of a multi-group effort at the PBRC and will result in the submission of a Program Project Grant proposal in early 2009. Secondly, Dr. Keller has worked with others at PBRC to establish the Institute for Dementia Research & Prevention. This institute will include a longitudinal study of aging and dementia in individuals in Louisiana aged 60 and over, as well as include a platform for the identification of therapeutics for the prevention of dementia. Those interested in learning more on any of these research efforts, or wanting to participate in these research efforts, are encouraged to contact the IDRP at (225) 763-2973 or dementia@pbrc.edu Dr. Keller for more details.
Department: Aging and Neurodegeneration
NIH/NIA 2PO1 AG005119 (Keller-Principal Investigator)
“The RAGE receptor and beta amyloid induced oxidative stress toxicity”
This project of the PPG examines the mechanism by which RAGE signaling contributes to A-beta induced toxicity and oxidative stress.
NIH/NIA 1RO1 AG025771 (Keller-Principal Investigator)
“Dietary restriction, aging and the proteasome”
This project quantified the changes in proteasome function in non-CNS tissues (immune, skeletal, hepatic, cardiovascular systems) that occur in response to aging and dietary restriction. Additionally, this grant will examine the effects of proteasome inhibition on non-CNS cells, and determine which features of aging are mediated by proteasome inhibition. These studies also explore the relationship between protein synthesis and protein degradation in non-CNS systems.
NIH/NIA 1RO1 AG029885 (Keller-Principal Investigator)
“Dietary restriction and proteasome mediated protein degradation in the CNS”.
This project quantified the changes in proteasome function in the CNS that occurs in response to aging and dietary restriction. Additionally, this grant will examine the effects of proteasome inhibition on CNS cells, and determine which features of aging are mediated by proteasome inhibition in the CNS. These studies also explore the relationship between the proteasome and oxidized protein regulation in the CNS.
Alzheimer’s Association Investigator Initiated Research Grant (Keller-Principal Investigator)
“HDAC inhibitors in in vitro and in vivo models of beta amyloid toxicity”
The goal of this proposal is to elucidate the therapeutic potential of histone deacytlase (HDAC) inhibitors in experimental model of beta amyloid toxicity. HDACs are commonly utilized in the treatment of some cancers and may provide benefit towards beta amyloid toxicity. These studies are intended to elucidate the ability of these compounds to be therapeutic in AD.
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Alzheimer's & dementia (New York, N. Y.)no. 4 (2023): e12422-e12422
Cranio-Orbital Mass Lesionspp.11-16, (2023)
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2023)
Journal of the International Neuropsychological Societyno. s1 (2023): 694-694
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