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Research Interests
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
Research Interests
Papers共 427 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
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期刊级别
合作者
合作机构
LEUKEMIAno. 1 (2024): 226-226
Cytotherapy (2024)
Cancer Researchno. 6_Supplement (2024): 44-44
Yu-Hsiang Chen, Jaehyun Lee, Mengchuan Zhuang, Timothy Bi, Yashwanth Lagisetty, Satpreet Singh, Alejandro Velarde, Hui Yang,Gheath Al-Atrash, Gabriela Rondon, Elizabeth Shpall, Fatima Jelloul,
Experimental Hematology (2024): 104367
Geraldine Paulus, Benjamin Lee, Preethi Sankaran,Tanzila Rahman,Jessica Jimenez, Delainey O'Connor, Simon Yue, Yu Huang, Melissa Bikowitz,Sarah Jaffe, Shawn O'Malley, Bhupal Ban,
CANCER RESEARCHno. 6 (2024): 1236-1236
Cancer immunology researchno. 5 (2024): 530-543
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Author Statistics
#Papers: 427
#Citation: 13498
H-Index: 55
G-Index: 112
Sociability: 7
Diversity: 0
Activity: 1
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