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Jeffrey Kordower, PhD, is an international authority in the area of movement disorders, with special expertise in experimental therapeutic strategies for Parkinson’s disease. He has published landmark papers in the area of cell replacement strategies and pathogenesis, including the first demonstration that fetal dopaminergic grafts can survive, innervate, and form synapses in patients with PD and the demonstration of the presence of Lewy bodies in fetal grafts. With regards to gene therapy, he published the lead article in Science demonstrating that gene delivery of the trophic factor GDNF can prevent the emergence of motor symptoms and nigrostriatal degeneration in a pre-clinical model of PD. Follow-up studies using neurturin have led to clinical trials. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease.
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论文共 123 篇作者统计合作学者相似作者
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Nicole J. Corbin-Stein,Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta,Fredric P. Manfredsson,Jeffrey H. Kordower,Ashley S. Harms
Acta Neuropathologica Communicationsno. 1 (2024): 1-17
Bryan A. Killinger,Jeffrey H. Kordower, Shernaz Walton,Alexis Fenyi, Tyler Tittle,Solji Choi,Ellen Sidransky, G. Higgs Paul,Ronald Melki
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 6 (2021): 933-945
user-5bd69975530c70d56f390249(2021)
Neurologyno. 11 (2020): 481-494
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