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Work on aldehyde oxidase (AO)- AO continues to be of increasing importance in drug metabolism and an early understanding of binding and kinetics will help us avoid expensive failures in the clinic. Such failures have already been documented for AO, and a general awareness of the problem now exists. However, models for AO’s role in human metabolism are particularly significant since animal models fail to predict human AO (hAO) affinities or clearance values. The major impact of this research will be in decreasing drug development time and the cost in human life associated with incomplete information when a drug candidate enters clinical trials.
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Nature communicationsno. 1 (2024): 5149-5149
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Andreea Manole,Thomas Wong, Amanda Rhee, Sammy Novak, Shao-Ming Chin, Katya Tsimring, Andres Paucar,April Williams, Traci Fang Newmeyer,Simon T Schafer,Idan Rosh,Susmita Kaushik,
Cell reportsno. 12 (2023): 113466-113466
Nature Reviews Neurologyno. 7 (2023): 434-443
Research Square (Research Square) (2021)
Science (New York, N.Y.)no. 6537 (2021): 91-94
John T. Rodgers,Jeffrey P. Jones
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