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Work on aldehyde oxidase (AO)- AO continues to be of increasing importance in drug metabolism and an early understanding of binding and kinetics will help us avoid expensive failures in the clinic. Such failures have already been documented for AO, and a general awareness of the problem now exists. However, models for AO’s role in human metabolism are particularly significant since animal models fail to predict human AO (hAO) affinities or clearance values. The major impact of this research will be in decreasing drug development time and the cost in human life associated with incomplete information when a drug candidate enters clinical trials.
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Research Square (Research Square) (2021)
John T. Rodgers,Jeffrey P. Jones
Biochemical pharmacology (2018): 69-78
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