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个人简介
Professor Cole is a microbial physiologist interested in how bacteria adapt to oxygen starvation or excess. Recent work has focused on how enteric bacteria protect themselves against nitric oxide generated either by other bacteria, or as a protection mechanism of their mammalian hosts. He currently collaborates with Dr. Amanda Rossiter on projects that include how bacteria survive the human immune response, and their roles in gastric cancer.
Research description
Genetic regulation of anaerobic bacterial metabolism of nitrate and nitrite
Oxygen, nitrate and nitrite regulate the synthesis of many enzymes required for bacteria to grow anaerobically. Such 'global responses' involve transcription factors such as FNR, NarL and NarP which respond to signals generated by oxygen, nitrate and nitrite. How are these various regulatory signals coordinated to achieve regulated gene expression? How are the promoters of the genes organised and how do the factors interact with RNA polymerase? This is a joint project with Professor Steve Busby.
研究兴趣
论文共 339 篇作者统计合作学者相似作者
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biorxiv(2024)
Harriet J. Giddings, Ana Teodósio,Jack L. McMurray,Kelly Hunter, Zainab Abdawn,Jeffrey A. Cole, Claire D. Shannon-Lowe, Amanda E. Rossiter-Pearson
crossref(2024)
New biotechnology (2024): 32-32
Jessica Gray,Von Vergel L Torres,Emily CA Goodall,Samantha A McKeand, Danielle Scales, Christy Collins, Laura Wetherall, Zheng Jie Lian,Jack A Bryant,Matthew T Milner,Karl A Dunne,Chris Icke,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Jessica Gray, Von Vergel L Torres,Emily CA Goodall, Samantha A McKeand, Danielle Scales, Christy Collins, Laura Wetherall, Zheng Jie Lian, Jack A Bryant, Matthew T Milner, Karl A Dunne, Chris Icke,
crossref(2024)
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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