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Jean-Noel Freund
Controle Metabolique et Nutritionnel en Oncologie;Institut de Recherche sur les Cancers de l'Appareil Digestif;Institut National de la Santeet de la Recherche Medicale;Institut de Recherche sur les Cancers de l'Appareil Digestif
Institut National de la Santeet de la Recherche Medicale
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基本信息
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Bio
The translational cancer research laboratory of INSERM and University of Strasbourg, UMR-S1113 / IRFAC, is located nearby the University Hospital of Strasbourg-Hautepierre (CHU), in close vicinity to the clinical Institute of Cancer Strasbourg Europe (ICANS). It brings together scientists, clinicians and methodologists whose goal is to provide a better understanding of (i) the mechanisms of tumor initiation (Team 1), (ii) the response to treatments (Team 2) and (iii) the role of stem cells in cancer (Team 3), with the aim of developing innovative therapies.
The Team 1, "Stem Cell Emergence & Tumor Initiation" , addresses mechanisms of embryogenesis and tissue homeostasis, whose alteration is involved in tumor initiation. It comprises 2 groups entitled « Intestinal Identity: from Stem Cells to Pathologies » and « Human Hematopoiesis and Leucemogenesis » focusing on the digestive and hematopoietic systems. Studies concern stem cells, their emergence during development, their homeostatic interactions with their cellular and molecular microenvironment. and their deregulation in cancer to produce cancer stem cells. Particular attention is paid on transcription factors (Cdx2, Taf4), signaling pathways (RAS-Angiotensin, BCR, TLR) and adhesion molecules (Mucdhl).
Research Interests
Papers共 172 篇Author StatisticsCo-AuthorSimilar Experts
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Rebecca Scarfo,Lauren N. Randolph,Monah Abou Alezz, Mahassen El Khoury, Amelie Gersch,Zhong-Yin Li,Stephanie A. Luff,Andrea Tavosanis, Giulia Ferrari Ramondo,Sara Valsoni,Sara Cascione, Emma Didelon,
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crossref(2023)
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Rebecca Scarfò,Monah Abou Alezz, Mahassen El Khoury, Amélie Gersch,Zhong-Yin Li,Stephanie A. Luff,Sara Valsoni,Sara Cascione, Emma Didelon,Ivan Merelli,Jean-Noël Freund,Christopher M. Sturgeon,
EXPERIMENTAL HEMATOLOGY (2023): S44-S44
crossref(2023)
Arteriosclerosis, thrombosis, and vascular biologyno. 8 (2023): 1494-1509
Cell Death & Differentiationno. 3 (2023): 839-853
Maria Virginia Giolito, Theo La Rosa,Diana Farhat, Serguei Bodoirat,Gabriela D. A. Guardia,Claire Domon-Dell,Pedro A. F. Galante,Jean-Noel Freund,Michelina Plateroti
MOLECULAR ONCOLOGYno. 22 (2022): 3975-3993
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Author Statistics
#Papers: 180
#Citation: 8001
H-Index: 42
G-Index: 87
Sociability: 7
Diversity: 0
Activity: 1
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