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个人简介
Our research aims at answering fundamental questions derived from industrial problems/limitations and is organized around a wide range of yeast applications in fermentation processes. Our research is sketched around three major themes.
We are interested to understand the molecular basis of complex industrially relevant traits of domesticated but also wild yeasts. In particular, we focus our attention on brewing related phenotypes, such as flavour and off-flavour formation during wort fermentation, wort sugar assimilation and cold tolerance.
Rewiring central metabolism to supply optimally building block intermediates for synthesis of added value chemicals. In the recent years, we applied these concepts on two different organisms S. cerevisiae and the filamentous fungi Penicillium chrysogenum for the biosynthesis of plant secondary metabolites of the flavonoid family and b-lactam/cephalosporin antibiotics respectively.
Both resolving complex traits and central and product metabolisms engineering require access a broad molecular toolbox to effectively achieved the required modifications. We are investigating molecular concepts enabling multiplexing genome editing events as simultaneous gene deletions and/or introduction of multiple gene expression cassettes and point mutations. In the recent years we harnessed the power of CRISPR genome editing tools. Although, the large majority of our research is centered around S. cerevisiae and Saccharomyces pastorianus models, implementation of CRISPR tools opens up genetic accessibility of other industrially relevant yeast species, the so called non-conventional yeasts e.g. Kluyveromyces, Ogataea, Yarrowia species creating a brand new playground for molecular- metabolic engineers.
研究兴趣
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Oriol Cabau-Peinado,Marijn Winkelhorst, Rozanne Stroek, Roderick de Kat Angelino,Adrie J.J. Straathof, Kunal Masania,Jean Marc Daran,Ludovic Jourdin
biorxiv(2024)
Anja K. Ehrmann,Anna K. Wronska,Thomas Perli,Erik A. F. de Hulster,Marijke A. H. Luttik,Marcel van den Broek, Clara Carqueija Cardoso,Jack T. Pronk,Jean Marc Daran
METABOLIC ENGINEERING (2024): 201-215
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Metabolic Engineering (2022): 1-13
biorxiv(2022)
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