基本信息
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个人简介
Over the past 20 years I have set up in Lille (France) together with my colleagues a successful comprehensive research and health care network fully dedicated to Inflammatory Bowel Diseases (Crohn’s disease [CD] and ulcerative colitis [UC]). Our research center was composed of 3 complementary groups: (1) a medical and surgical department which has performed many multicenter studies at the national (GETAID group) and international level; (2) an epidemiological group based upon the IBD North-Western Registry (EPIMAD); (3) a physiopathological group devoted to the study of immunological mechanisms and the development of new therapeutic targets in regulation of digestive inflammation. Thanks to the development of multiple local, national and international collaborations we have been able to make some important contributions to the pathophysiology of IBD. The most remarkable are the initiation in 1994 of collection and sampling of IBD families that eventually led to the identificationof NOD2 as a susceptibility gene for CD, the development in the 90’s of the ASCA test (anti-S. cerevisiae (mannan) antibodies) which is still the most sensitive and specific serologic marker for CD and elucidation of the potential role of Candida albicans in CD and the identification of a new pathovar of Escherichia coli (AIEC for adhesive invasive E.coli) associated with ileal CD. At the national level, I have been one of the leaders of the GETAID group, initiating and participating to many clinical trials that have helped to improve therapeutic strategies in IBD especially regarding the use of immunomodulators and biologics. Apart from international recognition, one of the biggest achievement of the GETAID has been the emergence of a new generation of young and bright European gastroenterologists with an interest in IBD. At the international level I have been involved as participant or primary investigator in most recent therapeutic trials with biologics.
研究兴趣
论文共 753 篇作者统计合作学者相似作者
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Scientific reportsno. 1 (2024): 186-186
Gastroenterologyno. 5 (2024): S-529
JOURNAL OF CROHNS & COLITISno. 5 (2024): I889-I890
Gastro Hep Advancesno. 4 (2024): 539-550
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2024)
Hein M. Tun,Lin Zhang,Jie Zhu,Ye Peng, Ling Lin,Jessica Y. Ching, CP Cheung,Shilan Wang,Wenye Xu,Ka Long Ip,Pui K. Cheong,Yingzhi Liu,
Gastroenterologyno. 5 (2024): S-552
Gastroenterologyno. 5 (2024): S-1431-S-1432
Laurent Peyrin-Biroulet, J Casey Chapman,Jean-Frederic Colombel,Flavio Caprioli, Geert D'Haens,Marc Ferrante,Stefan Schreiber,Raja Atreya,Silvio Danese,James O Lindsay,Peter Bossuyt,Britta Siegmund,
JOURNAL OF CROHNS & COLITISno. 5 (2024): I1254-I1255
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作者统计
#Papers: 756
#Citation: 59421
H-Index: 100
G-Index: 239
Sociability: 8
Diversity: 3
Activity: 369
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