He specializes in laser vision correction, cataract and cornea surgery, in addition to being a board certified cornea and vision correction surgery subspecialist.

A pioneer in laser eye surgery to correct nearsightedness, farsightedness and astigmatism, Dr. Pepose was the first to introduce LASIK vision correction to the St. Louis region. As one of the original 10 eye surgeons nationwide to participate in clinical trials of the excimer laser to correct mild to severe degrees of myopia and astigmatism, Dr. Pepose is regarded as a leading authority on laser vision correction diagnostics and outcomes. He was one of an elite group of eye surgeons that conducted a nationwide clinical trial that made LASIK available for the correction of farsightedness and astigmatism. Dr. Pepose is involved in many clinical trials related to the newest generation of multifocal lens implants for cataract patients, as well as clinical studies of more precise measurement devices for glaucoma and new treatments for presbyopia (age-related weakening of near vision).