基本信息
浏览量:3
职业迁徙
个人简介
A post at the Royal Brompton Hospital led to an interest in cystic fibrosis (CF), particularly host-pathogen interactions and her MD, under the supervision of Andy Bush and Eric Alton, focussed on the pathogenesis of Pseudomonas aeruginosa in the lung. Her clinical training was subsequently completed at Great Ormond Street Hospital in the departments of Respiratory Medicine and Infectious Diseases/ Immunology.
Professor Davies remains engaged in translational research in the field of CF. She is the clinical lead and Strategy Group member of the UK CF Gene Therapy Consortium; this Consortium was established in 2002 from 3 groups in the UK with CF gene therapy clinical trials experience (Imperial College/ Royal Brompton Hospital, Oxford University and Edinburgh University). The aim is to develop clinically relevant CFTR gene therapy. On the consortium trials she conducts the bronchoscopic assays and leads on the electrophysiological measurements (potential difference) both in the nose and lower airway.She is also heavily involved in clinical trial design and the validation of outcome measures, leading the Core Lung Clearance Index facility for the European CF Society Clinical Trials Network. She works closely with Prof Diana Bilton, the Adult CF clinical lead, on a number of commercially-sponsored clinical trials in CF, largely involving novel small-molecules directed at CFTR function.
She has other streams of research focussed on CF disease pathogenesis; together with Professor Andrew Bush, she has been engaged for several years in a programme of opportunistic bronchoscopic research, using bronchoalveolar lavage and endobronchial biopsies to define inflammatory and remodelling changes at various stages of childhood airways disease; she is currently supervising her 3rd post-graduate student in this area. As part of an interest in non-invasive measurements of airway disease, she has internal collaborations on projects including cyanogenesis in pseudomonas, bronchial blood flow measurements and pathogen-derived volatile organic compounds in exhaled breath. The Chronic Suppurative Lung Disease (CSLD) Consortium of the Respiratory Biomedical Research Unit, of which she is a member, has a strong emphasis on microbiology, in particular novel molecular detection tools.
Professor Davies remains engaged in translational research in the field of CF. She is the clinical lead and Strategy Group member of the UK CF Gene Therapy Consortium; this Consortium was established in 2002 from 3 groups in the UK with CF gene therapy clinical trials experience (Imperial College/ Royal Brompton Hospital, Oxford University and Edinburgh University). The aim is to develop clinically relevant CFTR gene therapy. On the consortium trials she conducts the bronchoscopic assays and leads on the electrophysiological measurements (potential difference) both in the nose and lower airway.She is also heavily involved in clinical trial design and the validation of outcome measures, leading the Core Lung Clearance Index facility for the European CF Society Clinical Trials Network. She works closely with Prof Diana Bilton, the Adult CF clinical lead, on a number of commercially-sponsored clinical trials in CF, largely involving novel small-molecules directed at CFTR function.
She has other streams of research focussed on CF disease pathogenesis; together with Professor Andrew Bush, she has been engaged for several years in a programme of opportunistic bronchoscopic research, using bronchoalveolar lavage and endobronchial biopsies to define inflammatory and remodelling changes at various stages of childhood airways disease; she is currently supervising her 3rd post-graduate student in this area. As part of an interest in non-invasive measurements of airway disease, she has internal collaborations on projects including cyanogenesis in pseudomonas, bronchial blood flow measurements and pathogen-derived volatile organic compounds in exhaled breath. The Chronic Suppurative Lung Disease (CSLD) Consortium of the Respiratory Biomedical Research Unit, of which she is a member, has a strong emphasis on microbiology, in particular novel molecular detection tools.
研究兴趣
论文共 470 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
American journal of respiratory and critical care medicineno. 8 (2024): 1039-1040
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2024): 1-15
Journal of applied physiology (Bethesda, Md. : 1985) (2023)
引用0浏览0WOS引用
0
0
EUROPEAN RESPIRATORY JOURNAL (2023)
C. Wainwright,S. McColley, P. McNally, M. Powers,F. Ratjen,J. Rayment, G. Retsch-Bogart, E. Roesch,N. Ahluwalia, C. Chu, P. Menon, T. Weinstock,
Journal of Cystic Fibrosis (2023): S70-S71
Frontiers in Microbiology (2023)
引用0浏览0引用
0
0
Journal of Cystic Fibrosis (2023): S21-S22
引用0浏览0引用
0
0
Journal of Cystic Fibrosisno. 1 (2023): 68-72
Pediatric pulmonologyno. 7 (2023): 1861-1863
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn