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个人简介
Jan C. Semenza is an environmental epidemiologist with over 25 years of experience in climate change and health research and a lead author of the Intergovernmental Panel on Climate Change (IPCC) AR6 report on climate change and infectious diseases.
He conducted his PhD at the Medical Research Council in Cambridge, UK in molecular cell biology where he isolated the receptor for heat-shock proteins, which was nominated “the receptor of the year” at the time. This receptor is used intracellularly to sort heat-shock proteins from proteins excreted from the cell and is found in all eukaryotic cells.
Subsequently, he obtained an MPH in environmental health with a focus on toxicology from UC Berkeley where his research focused on biomarkers of exposure. He applied molecular epidemiology to investigate the link between benzene exposure and leukaemia and explored gene-environment interactions in kidney cancer. Genetic predisposition increases the risk of certain environmental exposures according to specific susceptibility markers. These markers are found at high frequency in the general population but display a relatively low penetrance where the trait is not expressed in individuals in the absence of environmental exposures.
Besides his experimental research, he has also conducted a number of high-profile field investigations. He was an Epidemic Intelligence Service Officer at the U.S. Centers for Disease Control and Prevention (CDC) in 1995, when he led the CDC response to the heat wave in Chicago for which he received a Certificate of Commendation. He also conducted an investigation of a brain cancer cluster in Iowa and examined a number of environmental exposures. As part of his work with the regional offices of World Health Organization (WHO) including EURO, PAHO, and EMRO, he provided technical and scientific advice to the countries within their region, particularly on polio and measles eradication. He conducted public health projects in Uzbekistan, Sudan, Egypt, Denmark, Brazil, and Haiti through CDC, WHO, US Agency for International Development (USAID), and non-governmental organizations.
He was a faculty member at UC Berkeley, UC Irvine, Oregon Health and Science University, and at Portland State University where he taught in the Oregon Master Program of Public Health. Over the last 15 years he led the work on environmental and climatic drivers of infectious disease transmission at the European Centre for Disease Prevention and Control (ECDC), based in Stockholm, Sweden. Currently, he is associated with the Heidelberg Institute of Global Health, at the University of Heidelberg in Germany and is the co-lead of Working Group 1 and 2 of the Lancet Countdown in Europe.
研究兴趣
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The Lancet Regional Health - Europe (2024): 100947-100947
The Lancet Public Health (2024)
medRxiv (Cold Spring Harbor Laboratory) (2023)
The New England journal of medicineno. 23 (2023): 2175-2187
Joacim Rockloev,Jan C. Semenza,Shouro Dasgupta,ElizabethJ. Z. Robinson,Ahmed Abd El Wahed, Tilly Alcayna,Cristina Arnes-Sanz, Meghan Bailey,Till Baernighausen, Frederic Bartumeus, Carme Borrell,Laurens M. Bouwer,
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