Graduated from Charles University Prague Medical School, Czech republic with Charles Univerity Chairman Prize, trained in Czech republic, USA and the United Kingdom. Research Interest in Interventional Cardiology, initially Coronary intervention, later one of the worldwide pioneers in the field of structural and valvular interventions. Performed very first transcathether aortic valve intervention in the UK, PI of pivotal trials in the field, setting large trials in the field. Set the concept of Heart Team and initiated first multidisciplinary position statements in the field. Further interest also in interventional therapy and prevention of stroke, LAA, PFo closures, trialist and practising interventionist. Professor of Interventional Cardiology, Chair of the ESC Council For Stroke