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个人简介
The Kitajewski lab studies angiogenesis during cardiovascular development, in physiological settings, and in vascular pathologies. Our focus is on endothelial cell fate determination regulated by Notch signaling, GPCR signaling mediated by Chloride Intracellular Channels (CLIC), and matrix remodeling pathways regulated by anthrax toxin receptors (ANTXR). This work has uncovered mechanisms of embryonic, ovarian, retinal and tumor angiogenesis and contributed to our understanding of fertility, preeclampsia, vascular malformations, retinopathies, tumor angiogenesis and metastasis. The lab works actively to develop therapeutics for oncology use by targeting tumor angiogenesis, and his group developed Notch inhibitors, called “Notch decoys” that block tumor growth by reducing tumor vessel function.
研究兴趣
论文共 309 篇作者统计合作学者相似作者
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Scientific reportsno. 1 (2024): 13603-13603
Samuel Tanner Roach, Rishi Patel, Serena Thomas, Chinwe Ewenighi-Amankwah, Joseph Dufraine,L A. Naiche,Jan Kitajewski
Cancer Researchno. 6_Supplement (2024): 1496-1496
Cancer research communications (2024)
Stephanie R. Zack,Anja Meyer,Brian Zanotti,Michael V. Volin, Sania Deen, Neha Satoeya,Nadera Sweiss,Myles J. Lewis,Costantino Pitzalis,Jan K. Kitajewski,Shiva Shahrara
ANGIOGENESISno. 2 (2024): 273-283
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CANCER RESEARCHno. 5 (2023)
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作者统计
#Papers: 285
#Citation: 18781
H-Index: 72
G-Index: 136
Sociability: 7
Diversity: 1
Activity: 1
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