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Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal properties to improve regeneration. Plasticity is the main mechanism for functional recovery after damage to the nervous system. In childhood plasticity is largely turned off by extracellular matrix structures called perineeuronal nets. By moduating their function we can improve functional recovery and memory in the adult CNS. Interfacing the nervous system with electronics: We are developing a microchannel interface prosthesis which allows permanent extracellular recording from axons. This technology is being developed for control of bladder function in paralyzed human and veterinary patients, and for controlling prosthetic limbs.
Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal properties to improve regeneration. Plasticity is the main mechanism for functional recovery after damage to the nervous system. In childhood plasticity is largely turned off by extracellular matrix structures called perineeuronal nets. By moduating their function we can improve functional recovery and memory in the adult CNS. Interfacing the nervous system with electronics: We are developing a microchannel interface prosthesis which allows permanent extracellular recording from axons. This technology is being developed for control of bladder function in paralyzed human and veterinary patients, and for controlling prosthetic limbs.
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JOURNAL OF NEUROSCIENCEno. 26 (2023): 4775-4794
Jana Svobodova Burianova,Jiri Ruzicka, Lenka Gmitterkova, Tereza Spundova, Tereza Klausova, Noelia Martinez-Varea, Michaela Kralikova, Rostislav Turecek, Pavla Jendelova,Jessica Kwok,James Fawcett
IBRO Neuroscience Reports (2023): S504-S505
BIOMATERIALS (2023): 122393-122393
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Kristyna Karova, Zuzana Polcanova, Stepanka Suchankova, Lydia Knight,Bart Nieuwenhuis, Radovan Holota,Vit Herynek,Lucia Machova Urdzikova, Rostislav Turecek,Jessica C.F. Kwok,Joost Verhaagen,Richard Eva,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Shannon Tansley,Ning Gu,Alba Ureña Guzmán,Weihua Cai,Calvin Wong,Kevin C Lister, Einer Muñoz-Pino,Noosha Yousefpour,R Brian Roome, Jordyn Heal, Neil Wu,Annie Castonguay,
Jana Dubisova,Jana Svobodova Burianova,Lucie Svobodova, Pavol Makovicky,Noelia Martinez-Varea, Anda Cimpean,James W. Fawcett,Jessica C. F. Kwok,Sarka Kubinova
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