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个人简介
Trained in multiple disciplines (Physiology/Pharmacology, Metabolism, Genomics and Bioinformatics) I take a Systems approach to studying the connection between aging, human disease and exercise. A PhD studying mitochondrial biology was followed by 7yrs working in pharmaceutical drug-discovery (lead identification and lead development) followed by post-doctoral work in bioinformatics and RNA biology (Karolinska). My published work includes discovery of regulatory control of human mitochondrial responses to dynamic changes in energy demand (PMID: 9421469), discovery of the shared developmental origin of mitochondrial rich brown adipocytes with myogenic cells (PMID: 17360536) and production of detailed molecular models for human insulin-resistance (PMID: 29986096), neuromuscular aging (PMID: 31375147, 31168962) and how these interact with exercise (PMID: 32755574). This has allowed us to identify genes that govern clinical improvements in insulin resistance (PMID: 29986096) and potential new drug treatments (PMID: 35037854). As well as integrated approaches to modelling the human transcriptome we also develop new methods to enable study of coding and noncoding RNA regulation (PMID: 27095197, 35037854). This work has been funded through competitive grants from the MRC, BBSRC, EU, NIH and industry.
研究兴趣
论文共 168 篇作者统计合作学者相似作者
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Jonathan Cesare Mcleod,Changhyun Lim,Tanner Stokes, Jalil-Ahmad Sharif, Vagif Zeynalli, Lucas Wiens, Alysha C D'Souza, Lauren Colenso-Semple,James McKendry, Robert W Morton,Cameron J Mitchell, Sara Y Oikawa,
biorxiv(2024)
Advanced geneticsno. 2 (2023)
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作者统计
#Papers: 167
#Citation: 13534
H-Index: 48
G-Index: 116
Sociability: 6
Diversity: 3
Activity: 12
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