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Inhibitors of immune checkpoints (ICP) have revolutionised cancer treatment, leading to durable treatment responses in a proportion of patients suffering from previously incurable cancers. The efficacy of this class of drugs is dependent on their ability to trigger the patient’s cytolytic CD8+ T cells targeting tumour cells. However, the broad immune stimulatory capacity of ICP-blockade is associated with a high rate of immune related (irAE). The unpredictability of both efficacy and AEs in response to these agents is a growing concern. There are limited data relating to this heterogeneity of response and the development of irAE following administration of these agents. I will use the following approaches to define the mechanisms leading to the development of irAE.
1.Assessment of rare-patients with monogenic immune dysregulation leading to similar phenotypes as irAE to define candidate genes and pathways.
2.A unique and novel murine system that clonally tracks, self-antigen responsive cells that could cause irAE, in which we can disrupt prioritised pathways identified from our above screening.
1.Assessment of rare-patients with monogenic immune dysregulation leading to similar phenotypes as irAE to define candidate genes and pathways.
2.A unique and novel murine system that clonally tracks, self-antigen responsive cells that could cause irAE, in which we can disrupt prioritised pathways identified from our above screening.
Research Interests
Papers共 80 篇Author StatisticsCo-AuthorSimilar Experts
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Science immunologyno. 95 (2024): eade2094-eade2094
Munetomo Takahashi, Mikiya Tsunoda,Hiroyasu Aoki, Masaki Kurosu,Haru Ogiwara,Shigeyuki Shichino,David Bending,Shumpei Ishikawa,James E.D. Thaventhiran,Kouji Matsushima,Satoshi Ueha
biorxiv(2024)
biorxiv(2024)
Natureno. 7993 (2024): 189-194
Rebecca H. Boston, Rui Guan,Lajos Kalmar,Sina Beier,Emily C. Horner,Nonantzin Beristain-Covarrubias,Juan Carlos Yam-Puc,Pehuen Pereyra Gerber, Luisa Faria, Anna Kuroshchenkova,Anna E. Lindell,Sonja Blasche,
LIFE SCIENCE ALLIANCEno. 4 (2024)
Journal of extracellular vesiclesno. 2 (2024): e12412-e12412
Katrin Fischer,Aleksei Lulla, Tsz Y So, Pehuén Pereyra-Gerber,Matthew I J Raybould,Timo N Kohler,Juan Carlos Yam-Puc,Tomasz S Kaminski, Robert Hughes, Gwendolyn L Pyeatt, Florian Leiss-Maier, Paul Brear,
Nature biotechnologypp.1-11, (2024)
Munetomo Takahashi,Tsz Y. So,Kate Williamson,Zhaleh Hosseini,Katarzyna Kania, Michelle Ruhle,Tiffeney Mann, Martijn J. Schujis,Paul Coupland,Dean Naisbitt,Timotheus Y.F. Halim,Paul A. Lyons,
Juan Carlos Yam-Puc,Zhaleh Hosseini,Emily C. Horner,Pehuén Pereyra Gerber,Nonantzin Beristain-Covarrubias,Robert Hughes,Aleksei Lulla,Maria Rust,Rebecca Boston, Magda Ali,Katrin Fischer, Edward Simmons-Rosello,
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Author Statistics
#Papers: 78
#Citation: 1890
H-Index: 21
G-Index: 43
Sociability: 7
Diversity: 2
Activity: 123
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