My research interests centre on three areas: (i) using genetics to gain insight into the basis of psychosis and schizophrenia including characterising the clinical features of those carrying rare genetic variants (ii) studying the genetic, biological and psychosocial factors associated with treatment-resistant schizophrenia with the aim of stratifying those with psychosis to develop more personalised treatment approaches and (iii) investigating the nature and genetic basis of cognitive deficits across the psychosis spectrum including developing methods of on-line cognitive assessment.