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个人简介
Our laboratory investigates the interactions between axons and glial cells that drive assembly of myelinated fibers. Disruption of these interactions contributes to neurological disorders including multiple sclerosis. Our goal is to elucidate the biology of these interactions in order to ameliorate demyelination and promote repair in myelin disorders.
Finally, we are using genetic fate mapping strategies to examine the contributions of adult neural stems to the repair/remyelination of demyelinated axons in the adult CNS. We are particularly interested in the role of the Sonic hedgehog pathway in regulating stem cell repair and interactions of stem cells with microglia during demyelination/remyelination.
Finally, we are using genetic fate mapping strategies to examine the contributions of adult neural stems to the repair/remyelination of demyelinated axons in the adult CNS. We are particularly interested in the role of the Sonic hedgehog pathway in regulating stem cell repair and interactions of stem cells with microglia during demyelination/remyelination.
研究兴趣
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Developmental cellno. 5 (2024): 627-644.e10
Cold Spring Harbor perspectives in biology (2024)
biorxiv(2024)
Routledge eBookspp.413-448, (2023)
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