基本信息
浏览量:50
职业迁徙
个人简介
Our research is focused on the study of coronavirus-host cell receptor interactions, and the role played by glycosyltransferases in protein folding and subcellular targeting. In all cases, we take a structural approach involving x-ray crystallography and electron cryo-microscopy (Cryo-EM). We are currently working on SARS-CoV-2 and the seasonal coronaviruses that cause common cold-like symptoms. By studying the coronavirus Spike protein in complex with receptors and neutralizing antibodies, we seek to understand the basis for viral neutralization, immune evasion, and cross-species transmission. The work is also contributing to the development of antibody therapeutics and vaccines against SARS-CoV-2.
Our most recent work in the glycosyltransferase area deals with the protein-O-glycosyltransferases specific for the EGF-like domains found primarily in the Notch receptor and its ligands. It is not only uncovering how these enzymes ensure the proper folding and targeting of these important signalling molecules but the likely role that they played in the evolution of multicellular organisms. Our interest in glycosyltransferases also extends to those that modify N-glycans to mediate ER protein folding and lysosomal enzyme targeting, processes that are critical in protein homeostasis.
Our most recent work in the glycosyltransferase area deals with the protein-O-glycosyltransferases specific for the EGF-like domains found primarily in the Notch receptor and its ligands. It is not only uncovering how these enzymes ensure the proper folding and targeting of these important signalling molecules but the likely role that they played in the evolution of multicellular organisms. Our interest in glycosyltransferases also extends to those that modify N-glycans to mediate ER protein folding and lysosomal enzyme targeting, processes that are critical in protein homeostasis.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Camille Merhi, Anna C. Sullivan, Vaidehi T. Bhavaraju, Jamie M. Walker, Kevin F. Beiniek, Samy M. Abdullah,Arash Salardini,James Rini, Alicia Parker
NEUROLOGYno. 17 (2023)
引用0浏览0引用
0
0
Sabryna Nantel,Salma Sheikh-Mohamed,Gary Y. C. Chao,Alexandra Kurtesi,Queenie Hu,Heidi Wood,Karen Colwill,Zhijie Li, Ying Liu, Laurie Seifried,Benoîte Bourdin,Allison McGeer,
medRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
JOURNAL OF IMMUNOLOGYno. 1 (2022)
NATURE COMMUNICATIONSno. 1 (2021): 1806-8
Journal of molecular biologyno. 19 (2021): 167177-167177
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn