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Research Summary
I am interested in developing mathematical models of biological regulatory processes that integrate specific knowledge about protein-protein interactions. Together with collaborators as Los Alamos National Laboratory I have developed a simulation framework called BioNetGen that allows rule-based specification of biochemical reaction networks and provides both deterministic and stochastic modeling capabilities. My current research includes the development of specific models of signal transduction and the development of new stochastic simulation algorithms that will greatly broaden the scope of models that can be developed. Other research areas include model reduction, parameter estimation and uncertainty analysis, and automated model construction from databases of protein interactions.
I am interested in developing mathematical models of biological regulatory processes that integrate specific knowledge about protein-protein interactions. Together with collaborators as Los Alamos National Laboratory I have developed a simulation framework called BioNetGen that allows rule-based specification of biochemical reaction networks and provides both deterministic and stochastic modeling capabilities. My current research includes the development of specific models of signal transduction and the development of new stochastic simulation algorithms that will greatly broaden the scope of models that can be developed. Other research areas include model reduction, parameter estimation and uncertainty analysis, and automated model construction from databases of protein interactions.
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论文共 221 篇作者统计合作学者相似作者
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Neha Cheemalavagu, Karsen E. Shoger,Yuqi M. Cao,Brandon A. Michalides, Samuel A. Botta,James R. Faeder,Rachel A. Gottschalk
CELL SYSTEMSno. 1 (2024): 37-+
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Living journal of computational molecular scienceno. 1 (2023)
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Encyclopedia of Computational Neurosciencepp.1985-1988, (2022)
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Bilal Shaikh,Lucian P. Smith, Dan Vasilescu, Gnaneswara Marupilla,Michael Wilson,Eran Agmon, Henry Agnew,Steven S. Andrews,Azraf Anwar,Moritz Emanuel Beber,Frank Bergmann,David Brooks,
Nucleic Acids Research (2022)
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2022)
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Frontiers in systems biology (2022)
biorxiv(2022)
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