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Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal properties to improve regeneration. Plasticity is the main mechanism for functional recovery after damage to the nervous system. In childhood plasticity is largely turned off by extracellular matrix structures called perineeuronal nets. By moduating their function we can improve functional recovery and memory in the adult CNS. Interfacing the nervous system with electronics: We are developing a microchannel interface prosthesis which allows permanent extracellular recording from axons. This technology is being developed for control of bladder function in paralyzed human and veterinary patients, and for controlling prosthetic limbs.
Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal properties to improve regeneration. Plasticity is the main mechanism for functional recovery after damage to the nervous system. In childhood plasticity is largely turned off by extracellular matrix structures called perineeuronal nets. By moduating their function we can improve functional recovery and memory in the adult CNS. Interfacing the nervous system with electronics: We are developing a microchannel interface prosthesis which allows permanent extracellular recording from axons. This technology is being developed for control of bladder function in paralyzed human and veterinary patients, and for controlling prosthetic limbs.
Research Interests
Papers共 497 篇Author StatisticsCo-AuthorSimilar Experts
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Florian Buerger,Daanya Salmanullah,Lorrin Liang, Victoria Gauntner,Kavita Krueger, Maggie Qi,Vineeta Sharma, Alexander Rubin, David Ball,Katharina Lemberg,Ken Saida,Lea Maria Merz,
medRxiv : the preprint server for health sciences (2024)
Jana Svobodova Burianova,Jiri Ruzicka, Lenka Gmitterkova, Tereza Spundova, Tereza Klausova,Noelia Martinez-Varea,Michaela Kralikova,Rostislav Turecek,Pavla Jendelova,Jessica Kwok,James Fawcett
IBRO Neuroscience Reports (2023): S504-S505
Teresa S. McMillen,Andrew Leslie,Kenneth Chisholm,Susanne Penny, Jeffrey Gallant, Alejandro Cohen,Arik Drucker,James P. Fawcett,Devanand M. Pinto
Analytica chimica acta (2023): 341791-341791
Kristyna Karova, Zuzana Polcanova,Stepanka Suchankova, Lydia Knight,Bart Nieuwenhuis, Radovan Holota,Vit Herynek,Lucia Machova Urdzikova,Rostislav Turecek, Jessica C.F. Kwok,Joost Verhaagen,Richard Eva,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
biorxiv(2023)
Jana Dubisova,Jana Svobodova Burianova,Lucie Svobodova,Pavol Makovicky,Noelia Martinez-Varea, Anda Cimpean,James W. Fawcett, Jessica C.F. Kwok,Sarka Kubinova
Jiri Ruzicka,Marketa Dalecka, Kristyna Safrankova,Diego Peretti,Pavla Jendelova, Jessica C. F. Kwok,James W. Fawcett
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Author Statistics
#Papers: 498
#Citation: 44587
H-Index: 105
G-Index: 201
Sociability: 7
Diversity: 4
Activity: 60
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