基本信息
views: 755
Career Trajectory
Bio
He earned the 2018 Nobel Prize in Physiology or Medicine, which he shared with Dr. Tasuku Honjo, "for their discovery of cancer therapy by inhibition of negative immune regulation." Among his most notable discoveries are the determination of the T cell receptor structure and that CD28 is the major costimulatory molecule that allows full activation of naïve T cells and prevents anergy in T cell clones. His lab resolved a major controversy by demonstrating that CTLA-4 inhibits T-cell activation by opposing CD28-mediated costimulation and that blockade of CTLA-4 could enhance T cell responses, leading to tumor rejection in animal models. This finding and a great deal of persistence paved the way for the field of immune checkpoint blockade therapy for cancer. Work in his lab led to the development of ipilimumab, an antibody to human CTLA-4 and the first immune checkpoint blockade therapy approved by the FDA. Among many honors, he is a member of the National Academies of Science and Medicine and received the Lasker-Debakey Clinical Medical Research award in 2015. His current work seeks to improve immune checkpoint blockade therapies currently used by our clinicians and identify new targets to unleash the immune system in order to eradicate cancer.
Research Interests
Papers共 593 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Susana Castro-Pando, Rian M Howell,Le Li, Marilina Mascaro,Erika Y Faraoni,Olivereen Le Roux, David Romanin, Virginia Tahan,Erick Riquelme,Yu Zhang,Jay K Kolls,James P Allison,
Cancer immunology research (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 27 (2024): e2404661121-e2404661121
EUROPEAN JOURNAL OF CANCER (2024): 113501-113501
crossref(2023)
Cellno. 8 (2023): 1652-1669
Charlotte E. Ariyan,Mary Sue Brady,Robert H. Siegelbaum,Jian Hu,Danielle M. Bello, Jamie Rand,Charles Fisher,Robert A. Lefkowitz, Kathleen S. Panageas,Melissa Pulitzer,Marissa Vignali,Ryan Emerson,
crossref(2023)
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn