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个人简介
Research Interests:
Dr. Weiss's current research utilizes systems approaches integrating experimental biology at the molecular to organ levels with mathematical modeling and nonlinear dynamics to investigate the following areas:
1. Arrhythmia biology (with Peng-Sheng Chen, MD, Alan Garfinkel, PhD, Scott John, PhD, H. Karagueuzian, PhD, Thao Nguyen, MD, PhD, Riccardo Olcese, PhD, Zhilin Qu, PhD). The mechanisms of ventricular and atrial fibrillation are being studied using interdisciplinary experimental and mathematical approaches. The experimental component uses high resolution multielectrode and optical arrhythmia mapping in intact tissue and monolayers, and patch clamp and fluorescent dye studies in isolated cells. The theoretical component integrates nonlinear dynamics (including chaos theory) with computer simulations of spiral and scroll wave reentry in 2D and 3D cardiac tissue. The goal is to use insights from nonlinear dynamics to develop novel gene-, pharmacologic- and pacing-based therapeutic strategies.
2. Ischemia biology and cardioprotection (with Paavo Korge, PhD, Guillaume Calmettes, PhD, Peipei Ping, PhD). Viewing cardiac metabolism as a network of interlinked pathways (glycolysis, glycogenolysis and oxidative phosphorylation) regulated by multiple protein kinase signaling pathways, our goal is to integrate experimental and mathematical approaches to understand global system-wide responses of metabolism to stresses such as ischemia/reperfusion. A major focus is on the role of the mitochondrial permeability transition (MPT) in ischemia/reperfusion injury and cardioprotection, using biochemical and imaging techniques in isolated mitochondria and cardiac myocytes, as well as proteomic approaches in collaboration with the Ping laboratory. Major goals are to understand the mechanism by which mitochondrial ATP-sensitive K channel agonists, signaling by protein kinases and ROS, and metabolic pathways are cardioprotective, and to investigate the role of metabolic oscillations in accelerating cell death.
3. Systems genetics (with Mario Deng, MD, Alain Karma, PhD; Jake Lusis, PhD, Yibin Wang, PhD). Using the hybrid mouse diversity panel as an experimental genetics model, we are integrating network theory, bioinformatics and computational modeling to investigate how the expression patterns of groups of genes (gene modules) influence phenotypic responses to environmental stresses. We are exploring the potential of this novel approach, which we call Gene Module Association Study (GMAS) as an alternative to Genome Wide Association Study (GWAS) for analyzing the genetic basis of common polygenic diseases.
Dr. Weiss's current research utilizes systems approaches integrating experimental biology at the molecular to organ levels with mathematical modeling and nonlinear dynamics to investigate the following areas:
1. Arrhythmia biology (with Peng-Sheng Chen, MD, Alan Garfinkel, PhD, Scott John, PhD, H. Karagueuzian, PhD, Thao Nguyen, MD, PhD, Riccardo Olcese, PhD, Zhilin Qu, PhD). The mechanisms of ventricular and atrial fibrillation are being studied using interdisciplinary experimental and mathematical approaches. The experimental component uses high resolution multielectrode and optical arrhythmia mapping in intact tissue and monolayers, and patch clamp and fluorescent dye studies in isolated cells. The theoretical component integrates nonlinear dynamics (including chaos theory) with computer simulations of spiral and scroll wave reentry in 2D and 3D cardiac tissue. The goal is to use insights from nonlinear dynamics to develop novel gene-, pharmacologic- and pacing-based therapeutic strategies.
2. Ischemia biology and cardioprotection (with Paavo Korge, PhD, Guillaume Calmettes, PhD, Peipei Ping, PhD). Viewing cardiac metabolism as a network of interlinked pathways (glycolysis, glycogenolysis and oxidative phosphorylation) regulated by multiple protein kinase signaling pathways, our goal is to integrate experimental and mathematical approaches to understand global system-wide responses of metabolism to stresses such as ischemia/reperfusion. A major focus is on the role of the mitochondrial permeability transition (MPT) in ischemia/reperfusion injury and cardioprotection, using biochemical and imaging techniques in isolated mitochondria and cardiac myocytes, as well as proteomic approaches in collaboration with the Ping laboratory. Major goals are to understand the mechanism by which mitochondrial ATP-sensitive K channel agonists, signaling by protein kinases and ROS, and metabolic pathways are cardioprotective, and to investigate the role of metabolic oscillations in accelerating cell death.
3. Systems genetics (with Mario Deng, MD, Alain Karma, PhD; Jake Lusis, PhD, Yibin Wang, PhD). Using the hybrid mouse diversity panel as an experimental genetics model, we are integrating network theory, bioinformatics and computational modeling to investigate how the expression patterns of groups of genes (gene modules) influence phenotypic responses to environmental stresses. We are exploring the potential of this novel approach, which we call Gene Module Association Study (GMAS) as an alternative to Genome Wide Association Study (GWAS) for analyzing the genetic basis of common polygenic diseases.
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CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGYno. 9 (2020)
bioRxiv (Cold Spring Harbor Laboratory) (2019)
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