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Research Interests
The core interest of our group is to understand the regulatory principles of the human genome. Specifically, we investigate the molecular principles underlying epigenetic memory and inheritance in mammalian cells: how do cells establish the ‘epigenome’ to dictate gene expression programs and genome organization; how is the epigenome maintained and remodeled as cells divide and differentiate; and how do defects in these pathways lead to disease? We combine functional genomics CRISPR screens, cell biology, and biochemistry to answer our research questions.
Concurrently, we develop and apply CRISPR-based programmable technologies for editing the epigenome by writing/erasing DNA and histone modifications at any genomic locus, allowing us to perturb gene expression programs without changing the underlying DNA sequence.
The core interest of our group is to understand the regulatory principles of the human genome. Specifically, we investigate the molecular principles underlying epigenetic memory and inheritance in mammalian cells: how do cells establish the ‘epigenome’ to dictate gene expression programs and genome organization; how is the epigenome maintained and remodeled as cells divide and differentiate; and how do defects in these pathways lead to disease? We combine functional genomics CRISPR screens, cell biology, and biochemistry to answer our research questions.
Concurrently, we develop and apply CRISPR-based programmable technologies for editing the epigenome by writing/erasing DNA and histone modifications at any genomic locus, allowing us to perturb gene expression programs without changing the underlying DNA sequence.
研究兴趣
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Nature Communicationsno. 1 (2023): 6245-6245
CELLno. 9 (2021): 2503-+
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