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Inglese’s laboratory investigates strategies to identify chemical modulators targeting the molecular underpinnings of disease pathophysiology. His laboratory specializes in the design and reduction to practice of biochemical and cell-based assays for quantitative high-throughput screening (qHTS). Biological processes, including gene expression, posttranslational regulation, signaling and metabolism, that are involved in disorders ranging from infections to neuropathies have formed the basis of assays developed in his laboratory. The assays have been used to interrogate collections of clinically approved drugs to those composed of diverse novel substances, such as those found in microbial natural product extracts.
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论文共 276 篇作者统计合作学者相似作者
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Zishuo Cheng, Mahesh Aitha,Caitlyn A Thomas, Aidan Sturgill, Mitch Fairweather, Amy Hu, Christopher R Bethel, Dann D Rivera, Patricia Dranchak,Pei W Thomas, Han Li, Qi Feng,
Journal of chemical information and modeling (2024)
PloS oneno. 8 (2023): e0289707-e0289707
Sandeep Rana,Patricia Dranchak,Jayme L Dahlin,Laurence Lamy,Wenqing Li, Erin Oliphant,Jonathan H Shrimp, Girish H Rajacharya,Ravi Tharakan,David O Holland, Apryl S Whitten,Kelli M Wilson,
Cell chemical biologyno. 2 (2023): 221-233.e14
Methods in enzymology (2023): 1-41
Richard T Eastman,Radda Rusinova,Karl F Herold,Xi-Ping Huang,Patricia Dranchak,Ty C Voss, Sandeep Rana,Jonathan H Shrimp, Alex D White,Hugh C Hemmings,Bryan L Roth,James Inglese,
bioRxiv : the preprint server for biology (2023)
crossref(2023)
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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R H P van Neer,P K Dranchak,L Liu,M Aitha,B Queme, H Kimura,T Katoh, K P Battaile, S Lovell,J Inglese,H Suga
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