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James F. Holland, MDJames F. Holland, MD
Distinguished Professor of Neoplastic Diseases, Mount Sinai Medical Center, New York, New York
James F. Holland, MD | Class of 2013
A pioneer in clinical cancer research, Dr. Holland’s contributions to the field include his role at the National Cancer Institute in 1953, where he began the first combination chemotherapy program in acute leukemia. His subsequent work with Tom Frei, J Freireich, Jean Bernard and members of Acute Leukemia Group B on acute lymphoblastic leukemia in children resulted in its transformation from incurability to an over 80 percent survival rate. He constructed the 7 and 3 regimen for acute myelocytic leukemia which is used worldwide and first identified cisplatin for testicular cancer and doxorubicin for osteosarcoma. Novel research on adjuvant and neo-adjuvant chemotherapy in these diseases and in breast and ovarian cancers influenced treatment protocols.
He and colleagues have recently described HMTV, the human mammary tumor virus, present in 40 percent of American women’s breast cancers that is 90 to 95 percent homologous to MMTV, the cause of breast cancer in mice. Dr. Holland also collaborated with Tom Frei to edit Cancer Medicine, an important reference that covers science and clinical applications for cancers. This specialty text, now in its eighth edition with additional co-editors, continues to influence oncologists worldwide.
研究兴趣
论文共 316 篇作者统计合作学者相似作者
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Stella M. Melana,Irene Nepomnaschy, Michael Sakalian, Andrea Abbott, Jennifer Hasa,James F. Holland,Beatriz G.T. Pogo
crossref(2023)
James F. Holland, Robert C. Bast, John C. Byrd, Carlo M. Croce, Ernest T. Hawk, Fadlo R. Khuri,Raphael E. Pollock, Apostolia M. Tsimberadou, Christopher G. Willett, Cheryl L. Wilman
Holland-Frei Cancer Medicinepp.1-3, (2022)
Holland-Frei Cancer Medicinepp.1-9, (2017)
Stella M. Melana,Joseph Tripodi, Digna Nosike,Jaffer Shabnam, Polly Etkind,Beatriz G. T. Pogo,James F. Holland
Cancer Research (2017): 5757-5757
Springer eBookspp.635-640, (2017)
Robert C Bast Jr,Carlo M Croce, William N Hait,Waun Ki Hong,Donald W Kufe, Martine Piccart-Gebart,Raphael E Pollock,Ralph R Weichselbaum, Hongyang Wang,James F Holland
user-5ebe28d54c775eda72abcdf7(2017)
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Cancer Research (2016): 4062-4062
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