基本信息
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个人简介
Areas of Interest
Proteins start life as linear amino acid sequences and end up as beautifully folded, active structures. Dr. Bardwell's laboratory focuses on recently discovered machinery that drives protein folding in the cell. Powerful genetic, structural, and biophysical tools are being used to generate a detailed picture of how these folding machines work. Members of the Bardwell lab also use directed evolution to improve protein folding. They do this by asking organisms themselves to solve difficult protein-folding problems. By examining the solutions to these problems, they are better able to understand folding in the cell.
Honors & Awards
Elected Fellow, American Association for the Advancement of Science, 2013
Rowena G. Matthews Collegiate Professorship, University of Michigan, 2009
HHMI Investigator, 2005
研究兴趣
论文共 172 篇作者统计合作学者相似作者
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Bikash R. Sahoo, Vojc Kocman,Nathan Clark, Nikhil Myers,Xiexiong Deng,Ee L. Wong, Harry J. Yang,Anita Kotar, Bryan B. Guzman,Daniel Dominguez,Janez Plavec,James C. A. Bardwell
NUCLEIC ACIDS RESEARCHno. 8 (2024): 4702-4722
Biomolecular NMR Assignmentspp.1-7, (2024)
Royal Society of Chemistry eBookspp.199-216, (2023)
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Mark Dulchavsky,Rishav Mitra,Kevin Wu, Joshua Li,Karli Boer, Xiaomeng Liu,Zhiyao Zhang,Cristian Vasquez,Christopher T. Clark,Kaitrin Funckes,Kokila Shankar, Selene Bonnet-Zahedi,
Nature chemical biologyno. 11 (2023): 1406-1414
MACROMOLECULAR BIOSCIENCEno. 8 (2023): e2200528-e2200528
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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