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We participate in the revolution in fluorescence microscopy of biological systems. It is now possible to measure the spatial distribution of proteins and DNA loci with 30-nm precision in live cells and to track their motion in real time. The result is an unprecedented, high resolution view of biological structure and activity. Areas of current interest include: (1) The motion and spatial distribution of GFP-labeled species in live E. coli cells. Species of interest include RNA polymerase, ribosomes, architectural proteins, and specific DNA loci. The transcription/translation machinery (ribosomes, the nucleoid, and RNAP) all exhibit a remarkable level of spatial organization. (2) The time-resolved attack of antimicrobial agents on single bacterial cell membranes. Examples include LL-37, a human antimicrobial peptide, and synthetic random copolymers designed by the Gellman group. Simultaneous two-color imaging of the antimicrobial and cytoplasmic or periplasmic GFP yields unprecedented insight into the mechanism of attack. (3) The spatial distribution and function of proteins in the tomasyn family, mutations in which are believed to be important factors in Type-2 diabetes.
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International Journal of Molecular Sciencesno. 2057 (2022): 2057
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