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James LeeMolecular mechanisms of disease – from SNPs to disease biology
Genetic studies have successfully identified many regions of the human genome that increase an individual’s risk of autoimmune or inflammatory disease, but the molecular mechanisms that underpin these associations – and hence the reason they alter disease susceptibility – remain largely unknown. Our group is interested in uncovering the biology responsible for genetic associations in immune-mediated disease by combining genetics, genomics, molecular biology, and immunology-based approaches. We have a particular focus on the non-coding genome, including enhancers and non-coding RNA, and the role that they might play in regulating immune responses. Our goal is to not only shed new light on pathways involved in disease pathogenesis but to also provide novel therapeutic opportunities. Other interests include better understanding the genetic and biological determinants of prognosis in autoimmune, inflammatory and infectious diseases – as distinct from those pathways that drive disease development.
James LeeMolecular mechanisms of disease – from SNPs to disease biology
Genetic studies have successfully identified many regions of the human genome that increase an individual’s risk of autoimmune or inflammatory disease, but the molecular mechanisms that underpin these associations – and hence the reason they alter disease susceptibility – remain largely unknown. Our group is interested in uncovering the biology responsible for genetic associations in immune-mediated disease by combining genetics, genomics, molecular biology, and immunology-based approaches. We have a particular focus on the non-coding genome, including enhancers and non-coding RNA, and the role that they might play in regulating immune responses. Our goal is to not only shed new light on pathways involved in disease pathogenesis but to also provide novel therapeutic opportunities. Other interests include better understanding the genetic and biological determinants of prognosis in autoimmune, inflammatory and infectious diseases – as distinct from those pathways that drive disease development.
Research Interests
Papers共 272 篇Author StatisticsCo-AuthorSimilar Experts
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Communications Biologyno. 1 (2024): 1-13
C T Stankey,C Bourges, L M Haag, T Turner-Stokes, A P Piedade,C Palmer-Jones, I Papa, M Silva Dos Santos, Q Zhang, A J Cameron, A Legrini, T Zhang,
Natureno. 8016 (2024): 447-456
Lisa Whalley, Samuel Seldon,Graham Boustead, Rachel Lade,Dwayne Heard,Katie Read, Anna Callaghan,Shalini Punjabi,James Lee,Lucy Carpenter,Luis Neves
crossref(2024)
The lancet. Gastroenterology & hepatologyno. 5 (2024): 415-427
crossref(2024)
Yaoyuan Zhang,Rhiannon Morris, Grant J. Brown,Ayla May D. Lorenzo,Xiangpeng Meng,Nadia J. Kershaw,Pamudika Kiridena,Gaetan Burgio, Simon Gross,Jean Y. Cappello,Qian Shen,Hao Wang,
JOURNAL OF EXPERIMENTAL MEDICINEno. 4 (2024)
LANCET GASTROENTEROLOGY & HEPATOLOGYno. 5 (2024): 415-427
GASTROENTEROLOGYno. 4 (2023): S76-S77
Cell reports. Medicineno. 11 (2023): 101263-101263
Research Square (Research Square) (2023)
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