James M. Berger
教授
Center for Metabolism & Obesity Research
Institute for Basic Biomedical Sciences, School of Medicine, Johns Hopkins University;The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University;Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University
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基本信息
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个人简介
His research focuses on how multi-subunit assemblies use adenosine triphosphate (ATP) for transferring energy within the chromosome and controlling the flow of genetic information. Dr. Berger has a twenty year history of studying the fundamental mechanisms of enzymes that control cell proliferation and small molecule inhibitors that target such systems.
Dr. Berger and his team’s current research examines replication initiation and replisome assembly. To better understand how cells regulate and initiate replication of their genomes, Berger and his colleagues are studying origin-binding proteins, helicases, primases and accessory remodeling factors from a variety of organisms within the three cellular domains of life. Work from their group is revealing important information about the mechanisms of origin processing, primer synthesis, and macromolecular assembly that occur during replisome construction. Dr. Berger’s team is also studying the nucleic acid-dependent motors, with a particular focus on a variety of DNA- and RNA-dependent motor proteins. They are working to determine how such proteins interact with nucleic acids and partner proteins, and how they use ATP to drive the architectural changes required for catalysis and physical movement.
Dr. Berger and his team’s current research examines replication initiation and replisome assembly. To better understand how cells regulate and initiate replication of their genomes, Berger and his colleagues are studying origin-binding proteins, helicases, primases and accessory remodeling factors from a variety of organisms within the three cellular domains of life. Work from their group is revealing important information about the mechanisms of origin processing, primer synthesis, and macromolecular assembly that occur during replisome construction. Dr. Berger’s team is also studying the nucleic acid-dependent motors, with a particular focus on a variety of DNA- and RNA-dependent motor proteins. They are working to determine how such proteins interact with nucleic acids and partner proteins, and how they use ATP to drive the architectural changes required for catalysis and physical movement.
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Proceedings of the National Academy of Sciences of the United States of Americano. 5 (2024): e2319644121-e2319644121
NUCLEIC ACIDS RESEARCHno. 3 (2024): 1313-1324
Natureno. 7947 (2023): 237-238
Jaeyoon Lee, Meiling Wu,James T. Inman, Gundeep Singh,Seong ha Park,Joyce H. Lee,Robert M. Fulbright,Yifeng Hong, Joshua Jeong,James M. Berger,Michelle D. Wang
bioRxiv : the preprint server for biologyno. 1 (2023): 6844-17
NATUREno. 7947 (2023): 237-238
Proceedings of the National Academy of Sciences of the United States of Americano. 28 (2023)
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