基本信息
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Bio
Our general research interest is the structure and function of molecular motors in vitro and in vivo, with emphasis on understanding the molecular basis of muscle contraction. Our major areas of specific interest are the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the roles of the myosin family of molecular motors in eukaryotic cells, the regulation of actin and myosin interaction and their assembly states, and the biochemistry and regulation of the attachment of molecular motors to their corresponding cargo.
Our approaches include biochemical, genetic, biophysical and structural studies of actin, myosin, and associated proteins from eukaryotic cells. We have designed and developed in vitro assays for ATP-dependent movement of purified myosin on filaments reconstituted from purified actin. We have taken this assay to the single molecule level, using laser traps, total internal reflection fluorescence microscopy, and gold nanoparticle tracking. Myosin cloning and expression of mutagenized forms that are analyzed for altered functions is routine in our laboratory.
Our approaches include biochemical, genetic, biophysical and structural studies of actin, myosin, and associated proteins from eukaryotic cells. We have designed and developed in vitro assays for ATP-dependent movement of purified myosin on filaments reconstituted from purified actin. We have taken this assay to the single molecule level, using laser traps, total internal reflection fluorescence microscopy, and gold nanoparticle tracking. Myosin cloning and expression of mutagenized forms that are analyzed for altered functions is routine in our laboratory.
Research Interests
Papers共 505 篇Author StatisticsCo-AuthorSimilar Experts
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Frontiers in physiology (2024): 1390186-1390186
bioRxiv : the preprint server for biology (2024)
Methods in molecular biology (Clifton, N.J.) (2024): 169-189
Laura Sen-Martín,Ángel Fernández-Trasancos, Miguel Á. López-Unzu,Divya Pathak,Alessia Ferrarini,Verónica Labrador-Cantarero,David Sánchez-Ortiz,María Rosaria Pricolo,Natalia Vicente,Diana Velázquez-Carreras, Lucía Sánchez-García,Jose Ángel Nicolás-Ávila,
crossref(2024)
bioRxiv the preprint server for biology (2023)
CIRCULATION RESEARCHno. Suppl_1 (2023)
bioRxiv (2023)
bioRxiv : the preprint server for biology (2023)
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Author Statistics
#Papers: 505
#Citation: 48032
H-Index: 105
G-Index: 213
Sociability: 7
Diversity: 3
Activity: 37
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