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he worked as a research assistant in the Pharmaceutical Chemistry Department and at the Merck subsidiary InterX under Takeru Higuchi, Ooi Wong and Jose Alexander. His research focussed on chemical synthesis and testing of prodrugs and prodrug-like enhancers of skin permeability. After graduating, he was employed as a chemist at Alza Corporation in California for three years evaluating compounds that enhanced the electrotransport of drugs across the skin. His research on the serpins continued during his postdoc with Robin Carrell at the University of Cambridge, where he used X-ray crystallography to determine the mechanisms of serpin function. He was appointed principal investigator at the Cambridge Institute for Medical Research in 1999, University Reader in 2007 and Professor in 2011. His research focuses on serpin function and dysfunction, and on the regulation of blood coagulation. He has founded five biotech companies, including XO1 (recently acquired by Janssen Pharmaceuticals), AcpinteX (formerly Serpin Haemostatics), Z Factor, SuperX and Cambridge Protein Works.
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Journal of medicinal chemistryno. 6 (2023): 3785-3797
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