Jae Hyun Byun

The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research McMaster University

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Career Trajectory

Bio

Hello! My name is Jae and I’m an MD-PhD student at McGill University. The major focus of my scientific research career thus far, has been to explore the mechanisms that underlie the progression of a wide range of cardiometabolic diseases (e.g., atherosclerosis, diabetes, NAFLD) by elucidating the role of a serine protease known as PCSK9 and its ability to antagonize the LDL receptor.

Research Interests

Papers共 26 篇Author StatisticsCo-AuthorSimilar Experts

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Endoplasmic Reticulum Stress As a Driver and Therapeutic Target for Kidney Disease

Jae Hyun Byun,Paul F Lebeau,Jackie Trink,Nikhil Uppal,Matthew B Lanktree,Joan C Krepinsky,Richard C Austin

Nature reviews Nephrology（2025）

Cited0Views0WOSNATUREBibtex

Restoration of the ER Stress Response Protein TDAG51 in Hepatocytes Mitigates NAFLD in Mice

Tamana R. Yousof, Celeste C. Bouchard, Mihnea Alb,Edward G. Lynn,Sarka Lhotak, Hua Jiang,Melissa Macdonald,Hui Li,Jae H. Byun,Yumna Makda, Maria Athanasopoulos,Kenneth N. Maclean,Nathan J. Cherrington,Asghar Naqvi,Suleiman A. Igdoura,Joan C. Krepinsky,Gregory R. Steinberg,Richard C. Austin

The Journal of biological chemistryno. 2 (2024): 105655-105655

Cited1Views0WOSBibtex

Small Molecules Targeting GRP78 Mitigate Anti- GRP78 Autoantibody-Mediated Tissue Factor Procoagulant Activity in Cultured Endothelial Cells

Jack Chen,Edward G. Lynn,Hitesh Sharma,Jae H. Byun, Victor A. Kenyon,Kamlesh K. Sahu,D. Lorne Tyrrell,Michael Houghton,Peter L. Gross,Bernardo L. Trigatti,Bobby Shayegan,Richard C. Austin

Journal of Thrombosis and Haemostasis（2024）

Cited0Views0WOSBibtex

GDF10 is a Negative Regulator of Vascular Calcification

Khrystyna Platko,Gabriel Gyulay,Paul F. Lebeau,Melissa E. MacDonald,Edward G. Lynn,Jae Hyun Byun,Suleiman A. Igdoura,Rachel M. Holden,Anna Roubtsova,Nabil G. Seidah,Joan C. Krepinsky,Richard C. Austin

JOURNAL OF BIOLOGICAL CHEMISTRYno. 11 (2024)

Cited0Views0WOSBibtex

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor That Drives Metabolic Disease

Tamana Yousof,Jae Hyun Byun,Jack Chen,Richard C. Austin

Engineering（2023）

Cited3Views0Bibtex

A Metabolic Enhancer Protects Against Diet-Induced Obesity and Liver Steatosis and Corrects a Pro-Atherogenic Serum Profile in Mice

Khrystyna Platko,Paul F. Lebeau,Joshua P. Nederveen,Jae Hyun Byun,Melissa E. MacDonald,Jacqueline M. Bourgeois,Mark A. Tarnopolsky,Richard C. Austin

NUTRIENTS（2023）

Cited2Views0WOSBibtex

Scratching the Surface-An Overview of the Roles of Cell Surface GRP78 in Cancer

Jack Chen,Edward G. Lynn,Tamana R. Yousof,Hitesh Sharma,Melissa E. MacDonald,Jae Hyun Byun,Bobby Shayegan,Richard C. Austin

Biomedicines（2022）

Cited10Views0WOSBibtex

Inhibitory Antibodies Against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity

Jae Hyun Byun,Paul F. Lebeau,Khrystyna Platko,Rachel E. Carlisle,Mahi Faiyaz,Jack Chen,Melissa E. MacDonald,Yumna Makda,Tamana Yousof,Edward G. Lynn,Jeffrey G. Dickhout,Joan C. Krepinsky,Fiona Weaver,Suleiman A. Igdoura,Nabil G. Seidah,Richard C. Austin

Kidney360no. 8 (2022): 1394-1410

Cited10Views0WOSBibtex

Caffeine Blocks SREBP2-induced Hepatic PCSK9 Expression to Enhance LDLR-mediated Cholesterol Clearance

Paul F. Lebeau,Jae Hyun Byun,Khrystyna Platko,Paul Saliba,Matthew Sguazzin,Melissa E. MacDonald,Guillaume Paré,Gregory R. Steinberg,Luke J. Janssen,Suleiman A. Igdoura,Mark A. Tarnopolsky,S. R. Wayne Chen,Nabil G. Seidah,Jakob Magolan,Richard C. Austin

Nature Communications（2022）

Cited57Views0WOSNATUREBibtex

The Emerging Roles of Intracellular PCSK9 and Their Implications in Endoplasmic Reticulum Stress and Metabolic Diseases

Paul F. Lebeau,Khrystyna Platko,Jae Hyun Byun,Yumna Makda,Richard C. Austin

Metabolites（2022）

Cited11Views0WOSBibtex

Author Statistics

#Papers: 26

#Citation: 453

H-Index: 12

G-Index: 20

Sociability: 5

Diversity: 3

Activity: 19

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