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Our research interests lie at the interface of the tumour microenvironment, lymphatic biology and immunology. We believe the non-cancer cells comprising the stroma, especially those expressing a protein known as podoplanin, play an important role in helping to a) protect a new tumour from our immune system and b) develop and metastasise.
To understand how podoplanin expression within the tumour microenvironment is able to help drive tumour progression and modulation of the anti-tumour immune response, we take a multidisciplinary approach that integrates 3D co-culture systems, state-of-the-art microscopy techniques, genetically modified tumour models and in vivo imaging.
With the knowledge we gain, our ultimate goal is to develop therapeutic platforms that exploit these features to specifically target the tumour and supporting tissues.
To understand how podoplanin expression within the tumour microenvironment is able to help drive tumour progression and modulation of the anti-tumour immune response, we take a multidisciplinary approach that integrates 3D co-culture systems, state-of-the-art microscopy techniques, genetically modified tumour models and in vivo imaging.
With the knowledge we gain, our ultimate goal is to develop therapeutic platforms that exploit these features to specifically target the tumour and supporting tissues.
研究兴趣
论文共 51 篇作者统计合作学者相似作者
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Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
Advanced healthcare materialspp.e2303720-e2303720, (2024)
iScienceno. 4 (2024): 109546-109546
iSciencepp.109546, (2024)
Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
Karol Nowicki-Osuch,Lizhe Zhuang,Tik Shing Cheung, Emily L. Black,Neus Masqué-Soler,Ginny Devonshire,Aisling M. Redmond,Adam Freeman, Massimilliano di Pietro,Nastazja Pilonis,Wladyslaw Januszewicz, Maria O'Donovan,
crossref(2024)
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