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The Mueller laboratory explores the evolution and functions of structurally complex genomic regions and their associated genes in the germline. We use a combination of molecular and computational approaches to:
1. Better understand large (>10kb), nearly identical (>99% nucleotide identity), palindromic sequences on the mammalian X and Y chromosomes, where they are enriched, and on autosomes, where they are rare.
2. Learn how selfish genes harbored in complex genomic regions increase their own transmission to the next generation, via genetic and molecular analyses of germ cells in the mammalian testes and ovaries.
We aim to translate basic knowledge of these complex genomic regions and their associated genes into new understandings of human infertility, how genomes evolve, and how genes can disobey Mendelian inheritance.
1. Better understand large (>10kb), nearly identical (>99% nucleotide identity), palindromic sequences on the mammalian X and Y chromosomes, where they are enriched, and on autosomes, where they are rare.
2. Learn how selfish genes harbored in complex genomic regions increase their own transmission to the next generation, via genetic and molecular analyses of germ cells in the mammalian testes and ovaries.
We aim to translate basic knowledge of these complex genomic regions and their associated genes into new understandings of human infertility, how genomes evolve, and how genes can disobey Mendelian inheritance.
Research Interests
Papers共 26 篇Author StatisticsCo-AuthorSimilar Experts
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Jonathan M Alektiar,Mengrou Shan,Megan D Radyk, Li Zhang, Christopher J Halbrook,Lin Lin,Carlos Espinoza, Ivan F Mier, Brooke L Lavoie, Lucie Salvatore,Marina Pasca di Magliano,Lewis C Cantley,
PloS oneno. 6 (2024): e0303577-e0303577
Callie M. Swanepoel,Jacob L. Mueller
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