Jacob A McPhail - Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8P 5C2, Canada

基本信息

Career Trajectory

Bio

Currently investigating diseased states of key proteins driving Alzheimer's and Parkinson's diseases and developing these in vitro as novel neuroscience research tools. My PhD training focused on utilizing Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography to study the role of phosphatidylinositol kinases in signaling and disease.

Research Interests

Papers共 17 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Molecular Mechanisms of PI4K Regulation and Their Involvement in Viral Replication

Jacob A McPhail,John E Burke

Traffic (Copenhagen, Denmark)（2022）

Cited24Views0WOSBibtex

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα

Chiara Borsari,Erhan Keles,Jacob A. McPhail,Alexander Schaefer,Rohitha Sriramaratnam,Wojciech Goch,Thorsten Schaefer,Martina De Pascale,Wojciech Bal,Matthias Gstaiger,John E. Burke,Matthias P. Wymann

Journal of the American Chemical Societyno. 14 (2022): 6326-6342

Cited38Views0WOSBibtex

Development of Optimized Chemical Probes Targeting PI3Ka to Deconvolute the Role of Class I PI3Ks Isoforms in Insulin Signaling

Martina De Pascale,Chiara Borsari,Erhan Keles,Jacob McPhail,Alexander Schafer,Rohitha Sriramaratnam,Matthias Gstaiger,John Burke,Matthias Wymann

Cancer Research（2021）

Cited0Views0Bibtex

Volume Scanning, a Rational Approach to Covalent PI3Kα Inhibitors

Chiara Borsari,Erhan Keles,Jacob McPhail,Alexander Schafer,Rohitha Sriramaratnam,Martina De Pascale,Matthias Gstaiger,John Burke,Matthias P. Wymann

CANCER RESEARCH（2021）

Cited0Views0Bibtex

Defining How Viruses Manipulate Lipid Phosphoinositides Through Activation of PI4P Kinases to Mediate Viral Replication

John Burke,Jacob McPhail,Manoj Rathinaswamy,Meredith Jenkins

FASEB JOURNAL（2020）

Cited1Views0Bibtex

Structural Basis for Inhibitor Potency and Selectivity of Plasmodium Falciparum Phosphatidylinositol 4-Kinase Inhibitors

Stephen Fienberg,Charles J. Eyermann,Lauren B. Arendse,Gregory S. Basarab,Jacob A. McPhail,John E. Burke,Kelly Chibale

ACS Infectious Diseases（2020）

Cited17Views0WOSBibtex

Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections

Jacob A. McPhail,John E. Burke

Druggable Lipid Signaling Pathways Advances in Experimental Medicine and Biology（2020）

Cited17Views0WOSBibtex

(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and Mtor Kinase

Denise Rageot,Thomas Bohnacker,Erhan Keles,Jacob A. McPhail,Reece M. Hoffmann,Anna Melone,Chiara Borsari,Rohitha Sriramaratnam,Alexander M. Sele,Florent Beaufils,Paul Hebeisen,Doriano Fabbro,Petra Hillmann,John E. Burke,Matthias P. Wymann

Journal of Medicinal Chemistry（2019）

Cited51Views0WOSBibtex

Characterization of the Golgi C10orf76-Pi4kb Complex, and Its Necessity for Golgi PI4P Levels and Enterovirus Replication

Jacob A. McPhail,Heyrhyoung Lyoo,Joshua G. Pemberton,Reece M. Hoffmann, Wendy van Elst,Jeroen R. P. M. Strating,Meredith L. Jenkins,Jordan T. B. Stariha,Cameron J. Powell,Martin J. Boulanger,Tamas Balla,Frank J. M. van Kuppeveld,John E. Burke

EMBO Reports（2019）

Cited21Views0Bibtex

Erratum for Brunschwig Et Al., “UCT943, a Next-Generation Plasmodium Falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria”

Antimicrobial Agents and Chemotherapy（2018）

Cited51Views0WOSBibtex

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