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Our current major aims are to characterize RNA-binding by the >700 human C2H2 zinc finger transcription factors (C2H2-ZFPs) and explore their roles, together with those of their interacting proteins and other RNA-binding proteins, in genome organization and chromosome conformation, transcription by RNA polymerase II, mRNA modification, mRNA splicing, transcription termination, mRNA alternative 3'-end formation and polyadenylation, mRNA export to the cytoplasm, mRNA stability, and mRNA translation. In certain cases, we also investigate the involvement of these C2H2-ZFPs and the processes they regulate in various human diseases, especially cancer.
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Eliza S Lee,Harrison W Smith, Yifan E Wang, Sean SJ Ihn, Leticia Scalize de Olivera, Nevraj S Kejiou, Yijing L Liang,Syed Nabeel-Shah, Robert Y Jomphe,Shuye Pu,Jack F Greenblatt,Alexander F Palazzo
biorxiv(2024)
Debashish Ray,Kaitlin U. Laverty,Arttu Jolma,Kate Nie,Reuben Samson,Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk,Syed Nabeel-Shah,Mihai Albu,Hong Zheng,Gabrielle Perron,
Scientific Reportsno. 1 (2023): 1-15
BIO-PROTOCOLno. 11 (2023)
Molecular cellno. 6 (2023): 974-993.e15
PLoS pathogensno. 7 (2023): e1011477-e1011477
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Syed Nabeel-Shah,Jyoti Garg,Kanwal Ashraf, Renu Jeyapala,Hyunmin Lee, Alexandra Petrova, James D. Burns,Shuye Pu,Zhaolei Zhang,Jack F. Greenblatt,Ronald E. Pearlman,Jean-Philippe Lambert,
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