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Bio
The Nickoloff laboratory studies the molecular mechanisms that maintain eukaryotic genome stability in response to stress induced by DNA damage caused by low and high LET ionizing radiation and by genotoxic chemicals including cancer chemotherapeutics. Studies focus on DNA damage response networks including signaling pathways, checkpoint responses, chromatin regulatory systems and DNA repair pathways including homologous recombination and nonhomologous end-joining. Both yeast and mammalian cell systems are employed in studies involving the induction, mechanisms, consequences and genetic control of DNA damage responses. Dr. Nickoloff collaborates with scientists in Japan, England, Germany, the University of Colorado, the University of Nebraska and the University of Florida to improve our understanding of normal and tumor cell responses to radiotherapy and chemotherapy.
Research Interests
Papers共 138 篇Author StatisticsCo-AuthorSimilar Experts
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Cancer Researchno. 6_Supplement (2024): 7107-7107
Elizabeth A. Williamson, Leah Damiani,Andrei Leitao,Chelin Hu, Helen Hathaway,Tudor Oprea,Larry Sklar,Montaser Shaheen,Julie Bauman,Wei Wang,Jac A. Nickoloff,Suk-Hee Lee,
crossref(2023)
Nucleic acids researchno. 22 (2023): 12224-12241
crossref(2023)
Jac A. Nickoloff,Aruna S. Jaiswal,Neelam Sharma,Elizabeth A. Williamson, Manh T. Tran,Dominic Arris, Ming Yang,Robert Hromas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 23 (2023): 16903
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