基本信息
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Career Trajectory
Bio
Joshua Zimmerberg, M.D., Ph.D. trained in Developmental Enzymology, General Physiology, Membrane Biophysics and Neuroscience, and Cell Biology and early Development, with Olga Greengard, Alan Finkelstein, Adrian Parsegian, David Epel, and Daniel Mazia. More recently he trained in electron microscopy with Tom Reese. He builds teams of researchers to vigorously pursue the deeper understanding of membrane fusion, fission, phase, hydration, curvature, and poration as manifested in syncytia formation, cellular secretion, calcium homeostasis, collagen synthesis, viral infection, fertilization, organelle shape, protein translocation, channel architecture, toxoplasma entry, plasmodial egress, and adipose cell response to insulin. Having initiated studies on the long-_term deep tissue and dynamic single molecule microscopy of living cell membranes, he now focuses on membrane domains in viral assembly, viral entry into cells, lipid/protein interactions in pathological processes of HIV, apoptosis, malaria, sickle cell, insulin resistance, and traumatic brain injury. He is currently developing new viral-like particle models for the study of SARS-COV-2 pathogenesis, new mouse models for fragile sarcolemmal muscular dystrophies, and he is the PI of a clinical protocol to research biomarkers in subjects with these disorders. In NICHD, he is the Chief of the Section of Integrative Biophysics and a Senior Investigator. He recently fulfilled the maximum 8 year term as the Associate Scientific Director for the Division of Basic and Translational Biophysics, NICHD, the Division he founded. Prior to that, he founded and led both the Program in Physical Biology and the Laboratory of Cellular and Membrane Biophysics, NICHD, throughout their existence. In the NIH more generally, he is the Senior Advisor to the DDIR for Imaging and Biophysics. He is past Chairman, and currently Councilor, of the NIH Assembly of Scientists, elected representative of his peers.
Joshua Zimmerberg was named the 2021 recipient of the Sir Bernard Katz Award for Excellence in Research on Membrane Fusion, Fission, and Traffic. Bestowed by the Biophysical Society the award is named for the 1970 co-recipient of the Nobel Prize in Medicine or Physiology who discovered that neurotransmitters are released from membrane bound vesicles and travel across synapses to relay messages across neurons. Zimmerberg was recognized for his contribution to the understanding of how cell membranes fuse together and separate in exocytosis—the process of how membrane-bound vesicles are released from the cell, and endocytosis—the process of how membranes envelop material to take it into the cell. During his career, Dr. Zimmerberg’s discoveries have led to insights into how viruses enter cells, cellular invasion by the toxoplasma parasite and to an understanding of how the malaria parasite enters the cell, commandeers its resources, evades the immune system and progresses through the various stages of its life cycle.
Research Interests
Papers共 445 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of extracellular biologyno. 1 (2024): e139-e139
Neurosurgeryno. Supplement_1 (2023): 68-68
Biophysical journalno. 6 (2023): E1-E8
Journal of neuro-oncologyno. 1 (2023): 43-54
NEUROSURGERY (2023): 91-91
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Journal of extracellular biologyno. 4 (2023): e79-e79
bioRxiv the preprint server for biology (2022)
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Author Statistics
#Papers: 443
#Citation: 19318
H-Index: 74
G-Index: 133
Sociability: 7
Diversity: 3
Activity: 43
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