基本信息
views: 3
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Our laboratory studies molecular mechanisms of T cell activation and differentiation, and innate immune responses regulated by E3 ubiquitin ligases Cbl-b and Nedd4. We have identified several novel proteins targeted by Cbl-b in T cells and innate immune cells, and are investigating 1) whether and how Cbl-b regulates the development of T follicular helper cells (TFH), CD8+ cytotoxic T cells (Tc) and innate lymphoid cells (ILCs); 2) how Cbl-b regulates the innate immune cells sensing Candida albicans and other fungi; and 3) how Cbl-b controls sepsis and septic shock. In addition, we have also identified several novel substrates of Nedd4 in T cells and innate immune cells, are studying Nedd4 in T helper cell development and autoimmune/inflammatory diseases as well as in fungal infections and endotoxemia. Further understanding of these E3 ubiquitin ligases in innate and adaptive immunity will lead to the development of therapeutic invention for human diseases such as multiple sclerosis, allergic asthma, inflammatory bowel disease, and infectious diseases.
Research Interests
Papers共 104 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Human genomicsno. 1 (2023): 1-15
Cichun Wu,Jian Zhang,Huiwen Wang,Wei Zhang, Jingqing Liu, Nianqi Zhou,Keyu Chen,Ying Wang,Shifang Peng,Lei Fu
Journal of Biological Chemistryno. 5 (2022): 101938-101938
SSRN Electronic Journal (2022)
Qiuming Zeng,Na Tang,Yilei Ma, Hui Guo,Yixia Zhao,Rong Tang,Chengkai Yan,Song Ouyang,Wallace Y. Langdon,Huan Yang, Matthew C. O’Brien,Jian Zhang
Chakrapani Vemulawada,Pranav S. Renavikar,Michael P. Crawford,Scott Steward-Tharp, Hui Guo,Zhang Jian,Nitin J. Karandikar
JOURNAL OF IMMUNOLOGYno. 1 (2022): 1722-1732
Ling Huang,Yilei Ma, Hui Guo,Na Tang,Song Ouyang,Patrick Nuro-Gyina,Lijian Tao,Yusen Liu, Matthew C O'Brien,Wallace Y Langdon,Jian Zhang
Journal of immunology (Baltimore, Md. : 1950)no. 5 (2022): 991-1000
Load More
Author Statistics
#Papers: 107
#Citation: 3178
H-Index: 34
G-Index: 34
Sociability: 6
Diversity: 3
Activity: 29
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn