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The olfactory sense is essential for basic animal behaviors such as finding food, avoiding predators, and locating mating partners. Understanding the mechanism of olfaction has been accelerated by the discovery of an olfactory map at the first synapse. In mammals, these synapses are organized into 1000 glomeruli, each of which receives thousands of sensory neurons that express the same odorant receptor gene. The driving force of my lab is to find answers to such questions as: Is the pattern of glomerular activity evoked by a given odor related to the detection of this odor? How is the olfactory information represented and processed in the brain? How is olfactory valence represented in the brain? How is this representation modulated to meet the demands of different internal physiological states?
The long-term goal of my laboratory is to elucidate the mechanism of olfaction. We choose Drosophila as a model system for two main reasons. First, Drosophila has fewer than 50 glomeruli in the antennal lobe. A sophisticated genetic toolkit makes it possible to establish causality between neural circuit function and behavior. Second, despite the numerical simplicity, the anatomical organization of the Drosophila olfactory system is fundamentally similar to that of mammals, suggesting a shared mechanism for smell. Our current research activities aim to identify specific neural circuits underlying olfactory behaviors, investigate how different physiological states of an organism modulate the function of olfactory circuits, and establish causality between neural plasticity in specific neuron populations and olfactory behaviors.
The long-term goal of my laboratory is to elucidate the mechanism of olfaction. We choose Drosophila as a model system for two main reasons. First, Drosophila has fewer than 50 glomeruli in the antennal lobe. A sophisticated genetic toolkit makes it possible to establish causality between neural circuit function and behavior. Second, despite the numerical simplicity, the anatomical organization of the Drosophila olfactory system is fundamentally similar to that of mammals, suggesting a shared mechanism for smell. Our current research activities aim to identify specific neural circuits underlying olfactory behaviors, investigate how different physiological states of an organism modulate the function of olfactory circuits, and establish causality between neural plasticity in specific neuron populations and olfactory behaviors.
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论文共 66 篇作者统计合作学者相似作者
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NATURE METABOLISMno. 5 (2024): 1-10
crossref(2024)
Katie L. Dunton,Nathan G. Hedrick,Saber Meamardoost,Chi Ren, James R. Howe,Jing Wang,Cory M. Root,Rudiyanto Gunawan,Takaki Komiyama,Ying Zhang,Eun Jung Hwang
JOURNAL OF NEUROSCIENCEno. 10 (2024)
CURRENT OPINION IN BIOMEDICAL ENGINEERING (2023): 100428-100428
Research Square (Research Square) (2023)
Journal of neurogeneticsno. 1-2 (2023): 1-2
Brain research (2019): 158-166
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#Papers: 67
#Citation: 7087
H-Index: 33
G-Index: 51
Sociability: 5
Diversity: 3
Activity: 20
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