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The human major histocompatibility complex (MHC) encodes the most polymorphic proteins in the human genome and is associated with more diseases than any other region. Unravelling this complex of human loci, from sequence to function, will help to understand autoimmune diseases such as diabetes, multiple sclerosis and arthritis. The class I and class II molecules encoded by the MHC play a pivotal role in alerting the rest of the immune system to disease by interacting with receptors on T cells. A major part of our work concerns these molecules. Other genes embedded in the MHC provide additional clues to mechanisms of immune recognition.
The human major histocompatibility complex (MHC) encodes the most polymorphic proteins in the human genome and is associated with more diseases than any other region. Unravelling this complex of human loci, from sequence to function, will help to understand autoimmune diseases such as diabetes, multiple sclerosis and arthritis. The class I and class II molecules encoded by the MHC play a pivotal role in alerting the rest of the immune system to disease by interacting with receptors on T cells. A major part of our work concerns these molecules. Other genes embedded in the MHC provide additional clues to mechanisms of immune recognition.
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William H Palmer,Laura Ann Leaton,Ana Campos Codo,Bergren Crute, James Roest,Shiying Zhu,Jan Petersen,Richard P Tobin,Patrick S Hume,Matthew Stone,Adrie van Bokhoven, Mark E Gerich,
biorxiv(2023)
A. Dhuyser,T. Remen,M. Peres, V Chamberlain-Evans, N. Nemat-Gorgani, S. Clement,Rubio M. Therese,A. Campidelli,J. Trowsdale,A. Aarnink,J. Traherne
FRONTIERS IN IMMUNOLOGY (2022): 90-90
Muchaala Yeboah, Charys Papagregoriou,Des C Jones,HT Claude Chan,Guangan Hu,Justine S McPartlan, Torbjörn Schiött,Ulrika Mattson,C Ian Mockridge, Ulla-Carin Tornberg, Björn Hambe,Anne Ljungars,
bioRxiv (2020)
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