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职业迁徙
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Research Description
Plant seeds are an important renewable source of biosynthetic polymers, including protein, starch, oil and fiber. The amount of these biosynthates in harvested seed varies from negligible to a majority of the total mass. Though the biosynthetic pathways for seed storage compounds are mostly known, it is not clear how these pathways are regulated to produce higher quantities of oil versus starch or protein. Some of the ongoing research in my lab is centered on the development of quantitative proteomics approaches and applying these strategies towards seed filling in oilseeds, plants that accumulate oil as the primary storage reserve. We are using quantitative proteomics data to predict metabolic flow in diverse oilseeds such as castor, canola, soybean and sunflower with particular emphasis on carbon assimilation and intermediary metabolism.
I am also interested in the regulation and biochemistry of de novo fatty acid synthesis and triacylglycerol accumulation in oilseeds. The committed step for this pathway is catalyzed by acetyl-CoA carboxylase, a multienzyme complex that is exquisitely regulated to control flux through this pathway in response to cellular demand. My lab has recently found two new forms of regulation for this complex including a family of negative regulators and a new family of envelope-membrane scaffold proteins. Both of these gene families are unique to plants (and some algae), and thus present opportunities to unravel novel regulatory properties for this sophisticated protein complex.
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FRONTIERS IN PLANT SCIENCE (2024): 1372361-1372361
Minjae Kim,Gabriel Lemes Jorge,Moritz Aschern,Stephan Cuiné, Marie Huleux, Malika Mekhalfi,Jae-Seong Yang,Jay J. Thelen,Fred Beisson,Gilles Peltier,Yonghua Li-Beisson
biorxiv(2024)
SSRN Electronic Journal (2023): 100286-100286
Amr R.A. Kataya, Jose Roberto da Silva Nascimento,Chunhui Xu,Matthew G. Garneau,Somnath Koley,Athen Kimberlin,Brian Mooney,Doug K. Allen,Philip D. Bates,Abraham J. Koo,Dong Xu,Jay J. Thelen
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Metabolitesno. 3 (2023): 318-318
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