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I study ribonucleotide reductases (RNRs), which catalyze the conversion of nucleotides to deoxynucleotides and play an essential role in DNA replication and repair. I support a range of ongoing projects, including those related to the radical propagation pathway utilized by Class I RNRs, the interactions between protein subunits of Class I RNR, the regulation of RNRs, and the mechanisms behind clinical drugs. I also examine the biosynthesis, activation, and regulation of formation of the essential metallo-cofactors of RNRs in E. coli, S. cerevisiae, and humans.
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Chemical scienceno. 25 (2023): 6876-6881
Andreas Meyer, Annemarie Kehl,Chang Cui, Fehmke A. K. Reichardt, Fabian Hecker,Lisa-Marie Funk,Manas K. Ghosh,Kuan-Ting Pan,Henning Urlaub,Kai Tittmann,JoAnne Stubbe,Marina Bennati
Journal of the American Chemical Societyno. 25 (2022): 11270-11282
biorxiv(2022)
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