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Primary fields of research
We study the interface between transcription and other DNA-related processes, such as DNA repair, replication, and recombination.
One of the hallmarks of human disease, including cancer, is the deregulation of gene expression: genes that are supposed to be inactive become activated, or vice versa. Another characteristic of cancer cells is their unstable genomes. They are unable to repair or maintain the integrity of their DNA.
Over the last decade, it has also become increasingly clear that the process of transcription itself entails a significant risk for genome stability. The mechanisms that ensure the safe co-existence of transcription with DNA replication and pathways maintaining genome integrity are still poorly understood.
We seek to understand transcription and the maintenance of genome integrity using a unique combination of biochemical, genetic and cell biological techniques, primarily in human cells.
研究兴趣
论文共 167 篇作者统计合作学者相似作者
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Molecular cellno. 18 (2023): 3253-3267.e7
Annual review of biochemistryno. 1 (2023): 81-113
Cell reports methodsno. 12 (2022): 100368
Molecular cellno. 8 (2022): 1573-1588.e10
DNA repair (2022): 103343-103343
Sophie Ridewood,A. Barbara Dirac-Svejstrup,Stephen Howell,Anne Weston,Christine Lehmann, Asha Parbhu Patel,Lucy Collinson, Ryan Bingham,David Powell, Ambrosius Snijder,Jesper Q. Svejstrup,Edgar Deu
biorxiv(2021)
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