基本信息
浏览量:7
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Jonathan’s research focuses on understanding the metabolic programs that promote tumor growth as well as the activation, differentiation, and function of immune cells. By defining divergent metabolic programs of tumor and immune cells, his group seeks to define new targets for inhibiting tumor growth and enhancing cancer immunotherapy.
During his 20 years at Johns Hopkins, Jonathan’s lab sought to understand how immune cells integrate signals from the immune micro-environment to promote differentiation and function. This work identified a critical role for mTOR in contributing to this process and focused on the metabolic programs that regulate immune responses to cancer. By targeting metabolism, his group was able to enhance the function of anti-tumor-specific T cells and inhibit the generation and function of inhibitory cells such as MDSCs (myeloid-derived suppressor cells). By continuing to pursue this line of inquiry at Calico, Jonathan hopes to define novel targets for cancer therapy.
研究兴趣
论文共 422 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYno. 2 (2024): e184-e187
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYno. 2 (2024): e208-e211
Monali Praharaj, Fan Shen,Alex J Lee,Liang Zhao,Thomas R Nirschl,Debebe Theodros,Alok K Singh,Xiaoxu Wang, Kenneth M Adusei,Kara A Lombardo, Raekwon A Williams,Laura A Sena,
Cancer immunology researchno. 7 (2024): 854-875
PEDIATRIC BLOOD & CANCERno. 3 (2024): e30801-e30801
NURSING RESEARCHno. 2 (2024): 166-171
Samuel L Collins,Yee Chan-Li, Kevin Shenderov, Astrid Gillich, Andrew M Nelson, Jeffrey M Loube,Wayne A Mitzner,Jonathan D Powell,Maureen R Horton
bioRxiv : the preprint server for biology (2024)
Patricia LoRusso, Emiliano Calvo,Noboru Yamamoto,Chia-Chi Lin,J. Thaddeus Beck,David Sommerhalder,Do‐Youn Oh,John D. Powderly,Talia Golan, Linu Abraham,Joel S. Hayflick,Tamar Uziel,
Cancer Researchno. 8_Supplement (2023): CT257-CT257
Natureno. 7946 (2023): E12-E14
Blood (2023): 936
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn