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Research interests
Investigations from our laboratory range from therapeutic-focused research projects to basic science questions. We use a combination of electrophysiology, behavioural analysis and immunohistochemistry to evaluate different aspects of structure and function of sensory and motor systems under normal and injury conditions.
The use of photobiomodulation and novel biomaterials to promote nervous tissue recovery of peripheral nerves and the spinal cord are examples of therapeutic-focused projects. Photobiomodulation refers to the alteration of cellular biology in response to the absorption of light energy. Our team have demonstrated that the use of red (670 nm) light following injury to central or peripheral nervous tissues can improve behavioural and electrophysiological outcomes, alter the balance of inflammatory cell populations, reduce cell death and increase axonal sprouting. We have also found that red light treatment reduces signs of neuropathic pain in both our animal models of spinal cord and peripheral nerve injury. Neuropathic pain is currently poorly treated, and our studies may contribute toward new strategies with greater treatment success.
We have also used novel biomaterials to alter the cellular microenvironment around peripheral nerves.
Investigations from our laboratory range from therapeutic-focused research projects to basic science questions. We use a combination of electrophysiology, behavioural analysis and immunohistochemistry to evaluate different aspects of structure and function of sensory and motor systems under normal and injury conditions.
The use of photobiomodulation and novel biomaterials to promote nervous tissue recovery of peripheral nerves and the spinal cord are examples of therapeutic-focused projects. Photobiomodulation refers to the alteration of cellular biology in response to the absorption of light energy. Our team have demonstrated that the use of red (670 nm) light following injury to central or peripheral nervous tissues can improve behavioural and electrophysiological outcomes, alter the balance of inflammatory cell populations, reduce cell death and increase axonal sprouting. We have also found that red light treatment reduces signs of neuropathic pain in both our animal models of spinal cord and peripheral nerve injury. Neuropathic pain is currently poorly treated, and our studies may contribute toward new strategies with greater treatment success.
We have also used novel biomaterials to alter the cellular microenvironment around peripheral nerves.
研究兴趣
论文共 27 篇作者统计合作学者相似作者
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Tom F. Su, Jack D. Hamilton, Yiru Guo,Jason R. Potas,Mohit N. Shivdasani,Gila Moalem-Taylor,Gene Y. Fridman,Felix P. Aplin
JOURNAL OF NEURAL ENGINEERINGno. 2 (2024)
Tom F. Su, Jack D. Hamilton, Yiru Guo,Jason R. Potas,Mohit N. Shivdasani,Gila Moalem-Taylor,Gene Y. Fridman,Felix P. Aplin
biorxiv(2023)
Tom Fang Su, J. Hamilton, Yiru Guo,Jason R. Potas,Mohit N. Shivdasani,Gila Moalem‐Taylor,Gene Y. Fridman,Felix Aplin
bioRxiv (Cold Spring Harbor Laboratory) (2023)
FRONTIERS IN NEUROSCIENCE (2020): 500-500
Frontiers in Systems Neurosciencepp.1-34, (2020)
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