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Research Interests
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
Research Interests
Papers共 435 篇Author StatisticsCo-AuthorSimilar Experts
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Ze Tian,Chunhua Shi, Guojun Yang,Jason K. Allen, Qing Shi, Amin AL-Shami, Jill Wardell Olson,Melinda G. Smith,Qing Chang,Jasbir Kaur,Junping You,Timothy E. Lofton,
LEUKEMIAno. 1 (2024): 226-226
Cancer Researchno. 6_Supplement (2024): 44-44
Geraldine Paulus, Benjamin Lee, Preethi Sankaran, Tanzila Rahman,Jessica Jimenez, Delainey O'Connor, Simon Yue, Yu Huang, Melissa Bikowitz,Sarah Jaffe, Shawn O'Malley, Bhupal Ban,
Cancer Researchno. 6_Supplement (2024): 1236-1236
Cancer immunology researchno. 5 (2024): 530-543
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